skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study

Arthritis research & therapy, 2021-04, Vol.23 (1), p.108-108, Article 108 [Peer Reviewed Journal]

COPYRIGHT 2021 BioMed Central Ltd. ;COPYRIGHT 2021 BioMed Central Ltd. ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1478-6362 ;ISSN: 1478-6354 ;EISSN: 1478-6362 ;DOI: 10.1186/s13075-021-02495-x ;PMID: 33836822

Full text available

Citations Cited by
  • Title:
    Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study
  • Author: Zhu, Jingjing ; Niu, Zheng ; Alfredsson, Lars ; Klareskog, Lars ; Padyukov, Leonid ; Jiang, Xia
  • Subjects: Age ; Age at first birth ; Age at menarche ; Age at natural menopause ; Age factors in disease ; Biobanks ; Demographic aspects ; Estimates ; Females ; Fertility ; Health aspects ; Infertility ; Medicin och hälsovetenskap ; Menarche ; Mendelian randomization ; Menopause ; Puberty ; Rheumatoid arthritis ; Risk factors ; Variables ; Womens health
  • Is Part Of: Arthritis research & therapy, 2021-04, Vol.23 (1), p.108-108, Article 108
  • Description: Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sample Mendelian randomization (MR) study examining three relevant exposures, age at menarche (AAM), age at natural menopause (ANM), and age at first birth (AFB) with the risk of RA. We collected summary statistics from the hitherto largest GWAS conducted in AAM (N = 329,345), ANM (N = 69,360), AFB (N = 251,151), and RA (N  = 14,361, N  = 43,923), all of European ancestry. We constructed strong instruments using hundreds of exposure-associated genetic variants and estimated causal relationship through different MR approaches including an inverse-variance weighted method, an MR-Egger regression and a weighted median method. We conducted a multivariable MR to control for pleiotropic effect acting in particular through obesity and socioeconomic status. We also performed important sensitivity analyses to verify model assumptions. We did not find any evidence in support for a causal association between genetically predicted reproductive factors and risk of RA (OR  = 1.06 [0.98-1.15]; OR  = 1.05 [0.98-1.11], OR  = 0.85 [0.65-1.10]). Results remained consistent after removing palindromic SNPs (OR  = 1.06 [0.97-1.15], OR  = 1.05 [0.98-1.13], OR  = 0.81 [0.61-1.07]) or excluding SNPs associated with potential confounding traits (OR  = 1.03 [0.94-1.12], OR  = 1.04 [0.95-1.14]). No outlying instrument was identified through the leave-one-out analysis. Our MR study does not convincingly support a casual effect of reproductive factors, as reflected by age at menarche, age at menopause, and age at first birth, on the development of RA. Despite the largely augmented set of instruments we used, these instruments only explained a modest proportion of phenotypic variance of exposures. Our knowledge regarding this topic is still insufficient and future studies with larger sample size should be designed to replicate or dispute our findings.
  • Publisher: England: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 1478-6362
    ISSN: 1478-6354
    EISSN: 1478-6362
    DOI: 10.1186/s13075-021-02495-x
    PMID: 33836822
  • Source: Freely Accessible Journals
    SpringerOpen
    PubMed Central
    SWEPUB Freely available online
    ProQuest Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait