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Pathogenesis of pulmonary arterial hypertension: lessons from cancer
European respiratory review, 2013-12, Vol.22 (130), p.543-551
[Peer Reviewed Journal]
ERS 2013 2013 ;ISSN: 0905-9180 ;EISSN: 1600-0617 ;DOI: 10.1183/09059180.00007513 ;PMID: 24293470
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Title:
Pathogenesis of pulmonary arterial hypertension: lessons from cancer
Author:
Guignabert, Christophe
;
Tu, Ly
;
Le Hiress, Morane
;
Ricard, Nicolas
;
Sattler, Caroline
;
Seferian, Andrei
;
Huertas, Alice
;
Humbert, Marc
;
Montani, David
Subjects:
Animals
;
Antihypertensive Agents - therapeutic use
;
Antineoplastic Agents - therapeutic use
;
Drug Design
;
Familial Primary Pulmonary Hypertension
;
Humans
;
Hypertension, Pulmonary - drug therapy
;
Hypertension, Pulmonary - etiology
;
Hypertension, Pulmonary - genetics
;
Hypertension, Pulmonary - immunology
;
Hypertension, Pulmonary - metabolism
;
Hypertension, Pulmonary - pathology
;
Hypertension, Pulmonary - physiopathology
;
Mini-Review
;
Molecular Targeted Therapy
;
Neoplasms - drug therapy
;
Neoplasms - etiology
;
Neoplasms - genetics
;
Neoplasms - immunology
;
Neoplasms - metabolism
;
Neoplasms - pathology
;
Neoplasms - physiopathology
;
Risk Factors
;
Signal Transduction
Is Part Of:
European respiratory review, 2013-12, Vol.22 (130), p.543-551
Description:
Although the causal pathomechanisms contributing to remodelling of the pulmonary vascular bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous features with carcinogenesis have led to the emergence of the cancer-like concept. The major similarities concern the altered crosstalk between cells from different tissue types, unexplained proliferation and survival of pulmonary smooth muscle and endothelial cells, the metabolic (glycolytic) shifts, and the association with the immune system. However, major differences between PAH and cancer exist, including the absence of invasion and metastasis, as well as the pathogenic genes involved and the degrees of angiogenesis impairment and genetic instability. It is clear that PAH is not a cancer, but this cancer-like concept has opened a new field of investigation and raises the possibility that antiproliferative and/or oncological drugs may exert therapeutic effects not only in cancer, but also in PAH. Such analogies and differences are discussed here.
Publisher:
England: European Respiratory Society
Language:
English
Identifier:
ISSN: 0905-9180
EISSN: 1600-0617
DOI: 10.1183/09059180.00007513
PMID: 24293470
Source:
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
DOAJ Directory of Open Access Journals
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