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Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults

BMC medicine, 2021-09, Vol.19 (1), p.216-216, Article 216 [Peer Reviewed Journal]

2021. The Author(s). ;COPYRIGHT 2021 BioMed Central Ltd. ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1741-7015 ;EISSN: 1741-7015 ;DOI: 10.1186/s12916-021-02079-1 ;PMID: 34530818

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Title:
Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults
Author: Im, Pek Kei ; Millwood, Iona Y ; Kartsonaki, Christiana ; Guo, Yu ; Chen, Yiping ; Turnbull, Iain ; Yu, Canqing ; Du, Huaidong ; Pei, Pei ; Lv, Jun ; Walters, Robin G ; Li, Liming ; Yang, Ling ; Chen, Zhengming
Subjects: Adult ; Adults ; Age ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcoholic beverages ; Alcoholic liver disease ; Alcohols ; Antimitotic agents ; Antineoplastic agents ; Blood pressure ; Body mass index ; Cancer ; China - epidemiology ; Cirrhosis ; Cohort studies ; Diabetes ; Diseases ; Drinking ; Drinking behavior ; Drinking of alcoholic beverages ; Drinking patterns ; Drug tolerance ; Epidemiology ; Family income ; Family medical history ; Fatty liver ; Female ; Health aspects ; Health insurance ; Health risks ; Hepatitis B ; Humans ; Infections ; Liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Low alcohol ; Male ; Meals ; Medical research ; Medicine, Experimental ; Men ; Mortality ; Population ; Prospective Studies ; Questionnaires ; Risk analysis ; Risk Factors ; Sociodemographics ; Womens health
Is Part Of: BMC medicine, 2021-09, Vol.19 (1), p.216-216, Article 216
Description: Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability, which differ appreciably between Chinese and Western populations. The prospective China Kadoorie Biobank included 512,715 adults (41% men) aged 30-79 years recruited from ten areas during 2004-2008, recording alcohol intake, drinking patterns, and other characteristics. After median 10 years' follow-up, 2531 incident liver cancer, 2040 liver cirrhosis, 260 alcoholic liver disease (ALD), and 1262 non-alcoholic fatty liver disease (NAFLD) cases were recorded among 492,643 participants without prior cancer or chronic liver disease at baseline. Cox regression was used to estimate adjusted hazard ratios (HR) relating alcohol intake and drinking patterns to each disease. Overall, 33% of men and 2% of women drank alcohol regularly (i.e. at least weekly) at baseline. Among male current regular drinkers, alcohol consumption showed positive dose-response associations with risks of several major chronic liver diseases, with HRs per 280 g/week (i.e. around four drinks/day) higher usual alcohol intake of 1.44 (95% CI 1.23-1.69) for liver cancer (n = 547), 1.83 (1.60-2.09) for liver cirrhosis (n = 388), 2.01 (1.77-2.28) for ALD (n = 200), 1.71 (1.35-2.16) for NAFLD (n = 198), and 1.52 (1.40-1.64) for total liver disease (n = 1775). The association with ALD appeared stronger among men reporting flushing (i.e., with low alcohol tolerance). After adjustment for the total amount of weekly alcohol consumption, daily drinkers had significantly increased risk of ALD (2.15, 1.40-3.31) compared with non-daily drinkers, and drinking without meals was associated with significantly greater risks of liver cancer (1.32, 1.01-1.72), liver cirrhosis (1.37, 1.02-1.85), and ALD (1.60, 1.09-2.33) compared with drinking with meals. Female current regular drinkers had significantly higher risk of ALD, but not other liver diseases, than female abstainers. In Chinese men, alcohol intake was associated with significantly increased risks of several major chronic liver diseases, and certain drinking patterns (e.g. drinking daily, drinking without meals) may further exacerbate the disease risks.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1741-7015
EISSN: 1741-7015
DOI: 10.1186/s12916-021-02079-1
PMID: 34530818
Source: Geneva Foundation Free Medical Journals at publisher websites
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Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults

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