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Maternal Glucose and LDL-Cholesterol Levels Are Related to Placental Leptin Gene Methylation, and, Together With Nutritional Factors, Largely Explain a Higher Methylation Level Among Ethnic South Asians

Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.809916-809916 [Peer Reviewed Journal]

Copyright © 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher. ;info:eu-repo/semantics/openAccess ;Copyright © 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher 2021 Sletner, Moen, Yajnik, Lekanova, Sommer, Birkeland, Jenum and Böttcher ;ISSN: 1664-2392 ;EISSN: 1664-2392 ;DOI: 10.3389/fendo.2021.809916 ;PMID: 35002980

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  • Title:
    Maternal Glucose and LDL-Cholesterol Levels Are Related to Placental Leptin Gene Methylation, and, Together With Nutritional Factors, Largely Explain a Higher Methylation Level Among Ethnic South Asians
  • Author: Sletner, Line ; Moen, Aina E F ; Yajnik, Chittaranjan S ; Lekanova, Nadezhda ; Sommer, Christine ; Birkeland, Kåre I ; Jenum, Anne K ; Böttcher, Yvonne
  • Subjects: Adiposity - ethnology ; Adiposity - physiology ; Adult ; Asians - ethnology ; Blood Glucose - metabolism ; cholesterol ; Cholesterol, LDL - blood ; Cohort Studies ; Diabetes, Gestational - blood ; Diabetes, Gestational - ethnology ; DNA Methylation - physiology ; Endocrinology ; ethnicity ; Female ; Follow-Up Studies ; gestational diabetes ; Humans ; Leptin ; Leptin - metabolism ; methylation ; Nutritional Status - ethnology ; placenta ; Placenta - metabolism ; Pregnancy
  • Is Part Of: Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.809916-809916
  • Description: Leptin, mainly secreted by fat cells, plays a core role in the regulation of appetite and body weight, and has been proposed as a mediator of metabolic programming. During pregnancy leptin is also secreted by the placenta, as well as being a key regulatory cytokine for the development, homeostatic regulation and nutrient transport within the placenta. South Asians have a high burden of type 2 diabetes, partly attributed to a "thin-fat-phenotype". Our aim was to investigate how maternal ethnicity, adiposity and glucose- and lipid/cholesterol levels in pregnancy are related to placental leptin gene ( ) DNA methylation. We performed DNA methylation analyses of 13 placental CpG sites in 40 ethnic Europeans and 40 ethnic South Asians participating in the STORK-Groruddalen cohort. South Asian ethnicity and gestational diabetes (GDM) were associated with higher placental methylation. The largest ethnic difference was found for CpG11 [5.8% (95% CI: 2.4, 9.2), p<0.001], and the strongest associations with GDM was seen for CpG5 [5.2% (1.4, 9.0), p=0.008]. Higher maternal LDL-cholesterol was associated with lower placental methylation, in particular for CpG11 [-3.6% (-5.5, -1.4) per one mmol/L increase in LDL, p<0.001]. After adjustments, including for nutritional factors involved in the one-carbon-metabolism cycle (vitamin D, B12 and folate levels), ethnic differences in placental methylation were strongly attenuated, while associations with glucose and LDL-cholesterol persisted. Maternal glucose and lipid metabolism is related to placental methylation, whilst metabolic and nutritional factors largely explain a higher methylation level among ethnic South Asians.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English;Norwegian
  • Identifier: ISSN: 1664-2392
    EISSN: 1664-2392
    DOI: 10.3389/fendo.2021.809916
    PMID: 35002980
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    NORA Norwegian Open Research Archives
    PubMed Central(OpenAccess)
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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