Language:

Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression

International journal of molecular sciences, 2020-05, Vol.21 (10), p.3405 [Peer Reviewed Journal]

2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 by the authors. 2020 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms21103405 ;PMID: 32408480

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression
Author: Daiber, Andreas ; Steven, Sebastian ; Vujacic-Mirski, Ksenija ; Kalinovic, Sanela ; Oelze, Matthias ; Di Lisa, Fabio ; Münzel, Thomas
Subjects: Aging ; Angiotensin ; Angiotensin II ; Animals ; Antioxidants ; Cardiovascular diseases ; Cardiovascular Diseases - metabolism ; Crosstalk ; Cytochrome ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - metabolism ; Disease Progression ; endothelial dysfunction ; Enzymes ; Humans ; Hydrogen peroxide ; Hypertension ; Hypoxia ; Inflammation ; Inflammation - metabolism ; Ischemia ; Kinases ; Kindling ; kindling radicals ; Mitochondria ; Mitochondria - metabolism ; NAD(P)H oxidase ; NADPH oxidase ; NADPH Oxidases - metabolism ; Nitric oxide ; Nitrogen ; Oxidants ; Oxidation ; Oxidative stress ; Oxidizing agents ; Physiology ; Proteins ; Reactive Nitrogen Species - metabolism ; Reactive Oxygen Species - metabolism ; redox cross talk ; Review
Is Part Of: International journal of molecular sciences, 2020-05, Vol.21 (10), p.3405
Description: Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept has been proven by using the approach of genetic deletion of reactive oxygen and nitrogen species (RONS) producing, pro-oxidant enzymes as well as by the overexpression of RONS detoxifying, antioxidant enzymes leading to an amelioration of the severity of diseases. Vice versa, the development and progression of cardiovascular diseases is aggravated by overexpression of RONS producing enzymes as well as deletion of RONS detoxifying enzymes. We have previously identified cross talk mechanisms between different sources of RONS, which can amplify the oxidative stress-mediated damage. Here, the pathways and potential mechanisms leading to this cross talk are analyzed in detail and highlighted by selected examples from the current literature and own data including hypoxia, angiotensin II (AT-II)-induced hypertension, nitrate tolerance, aging, and others. The general concept of redox-based activation of RONS sources via "kindling radicals" and enzyme-specific "redox switches" as well as the interaction with redox-sensitive inflammatory pathways are discussed. Here, we present evidence for the existence of such cross talk mechanisms in the setting of diabetes and critically assess their contribution to the severity of diabetic complications.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms21103405
PMID: 32408480
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression

Searching Remote Databases, Please Wait