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Dynamic contrast-enhanced MRI shows altered blood–brain barrier function of deep gray matter structures in neuroborreliosis: a case–control study

European radiology experimental, 2023-09, Vol.7 (1), p.52-52, Article 52 [Peer Reviewed Journal]

The Author(s) 2023 ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;European Society of Radiology (ESR) 2023 ;ISSN: 2509-9280 ;EISSN: 2509-9280 ;DOI: 10.1186/s41747-023-00365-6 ;PMID: 37710058

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  • Title:
    Dynamic contrast-enhanced MRI shows altered blood–brain barrier function of deep gray matter structures in neuroborreliosis: a case–control study
  • Author: Lindland, Elisabeth S. ; Solheim, Anne Marit ; Andreassen, Silje ; Bugge, Robin ; Eikeland, Randi ; Reiso, Harald ; Lorentzen, Åslaug R. ; Harbo, Hanne F. ; Beyer, Mona K. ; Bjørnerud, Atle
  • Subjects: Biomarkers ; Blood ; Blood–brain barrier ; Cognitive ability ; Diagnostic Radiology ; Encephalitis (tick-borne) ; Gray matter ; Imaging ; Infections ; Internal Medicine ; Interventional Radiology ; Lyme neuroborreliosis ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Neuroradiology ; Original ; Original Article ; Pathophysiology ; Radiology ; Scandals ; Ultrasound
  • Is Part Of: European radiology experimental, 2023-09, Vol.7 (1), p.52-52, Article 52
  • Description: Background Main aim was assessment of regional blood–brain barrier (BBB) function by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with neuroborreliosis. Secondary aim was to study the correlation of BBB function with biochemical, clinical, and cognitive parameters. Methods Regional ethical committee approved this prospective single-center case–control study. Within 1 month after diagnosis of neuroborreliosis, 55 patients underwent DCE-MRI. The patient group consisted of 25 males and 30 females with mean age 58 years, and the controls were 8 males and 7 females with mean age 57 years. Pharmacokinetic compartment modelling with Patlak fit was applied, providing estimates for capillary leakage rate and blood volume fraction. Nine anatomical brain regions were sampled with auto-generated binary masks. Fatigue, severity of clinical symptoms and findings, and cognitive function were assessed in the acute phase and 6 months after treatment. Results Leakage rates and blood volume fractions were lower in patients compared to controls in the thalamus ( p  = 0.027 and p  = 0.018, respectively), caudate nucleus ( p  = 0.009 for both), and hippocampus ( p  = 0.054 and p  = 0.009). No correlation of leakage rates with fatigue, clinical disease severity or cognitive function was found. Conclusions In neuroborreliosis, leakage rate and blood volume fraction in the thalamus, caudate nucleus, and hippocampus were lower in patients compared to controls. DCE-MRI provided new insight to pathophysiology of neuroborreliosis, and can serve as biomarker of BBB function and regulatory mechanisms of the neurovascular unit in infection and inflammation. Relevance statement DCE-MRI provided new insight to pathophysiology of neuroborreliosis, and can serve as biomarker of blood–brain barrier function and regulatory mechanisms of the neurovascular unit in infection and inflammation. Key points • Neuroborreliosis is an infection with disturbed BBB function. • Microvessel leakage can be studied with DCE-MRI. • Prospective case–control study showed altered microvessel properties in thalamus, caudate, and hippocampus. Graphical Abstract
  • Publisher: Vienna: Springer Vienna
  • Language: English
  • Identifier: ISSN: 2509-9280
    EISSN: 2509-9280
    DOI: 10.1186/s41747-023-00365-6
    PMID: 37710058
  • Source: Springer Open Access
    PubMed Central
    Coronavirus Research Database
    ProQuest Central
    DOAJ Directory of Open Access Journals
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