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Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging

International journal of molecular sciences, 2021-03, Vol.22 (5), p.2522 [Peer Reviewed Journal]

2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 by the authors. 2021 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms22052522 ;PMID: 33802338

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Title:
Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging
Author: Lee, Namhun ; Oh, Se-Jong ; Park, Jang-Woo ; Nam, Kyung-Rok ; Kang, Kyung-Jun ; Lee, Kyo-Chul ; Lee, Yong-Jin ; Choi, June-Seek ; Seok, Jeong-Ho ; Choi, Jae-Yong
Subjects: Adults ; Animal models ; Animals ; Animals, Newborn - metabolism ; Animals, Newborn - physiology ; Anxiety ; Anxiety - metabolism ; Anxiety - physiopathology ; Anxiety Disorders - metabolism ; Anxiety Disorders - physiopathology ; Behavior, Animal - physiology ; Body weight ; Brain - metabolism ; Brain - physiology ; Depression - metabolism ; Depression - physiopathology ; Disease Models, Animal ; Dopamine receptors ; early life stress ; Exploratory Behavior - physiology ; Female ; Glutamatergic transmission ; Male ; Maternal Deprivation ; Maze Learning - physiology ; Mental disorders ; Mental health ; Molecular Imaging - methods ; Neuroimaging ; neurotransmission ; Neurotransmitter Agents - metabolism ; Neurotransmitters ; Phenotypes ; positron emission tomography ; Rats ; Rats, Sprague-Dawley ; Schizophrenia ; Stress ; Stress, Psychological - metabolism ; Stress, Psychological - physiopathology ; Swimming - physiology ; Trauma ; Wounds and Injuries - metabolism ; Wounds and Injuries - physiopathology
Is Part Of: International journal of molecular sciences, 2021-03, Vol.22 (5), p.2522
Description: Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms22052522
PMID: 33802338
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging

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