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In response to nocturnal dipping profile in chronic kidney disease: Searching for underlying mechanisms in order to prevent adverse events

Physiological reports, 2021-01, Vol.8 (24), p.e14674-n/a [Peer Reviewed Journal]

2020 The Authors. published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society ;2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;EISSN: 2051-817X ;DOI: 10.14814/phy2.14674 ;PMID: 33356009

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  • Title:
    In response to nocturnal dipping profile in chronic kidney disease: Searching for underlying mechanisms in order to prevent adverse events
  • Author: Jeong, Jinhee ; Park, Jeanie
  • Subjects: Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Humans ; Hypertension ; Kidney diseases ; Kidneys ; Letter to the Editor ; Letter to the Editors ; Patients ; Renal Insufficiency, Chronic ; Sympathetic nerves
  • Is Part Of: Physiological reports, 2021-01, Vol.8 (24), p.e14674-n/a
  • Description: Despite the high prevalence of non‐dipping BP patterns (Iimuro et al., 2013; Pogue et al., 2009) and its strong prognostic value for target organ damage and worse cardiovascular outcomes in patients with CKD (Choi et al., 2017; Jaques et al., 2018), there is a lack of knowledge in the pathophysiological mechanisms underlying non‐dipping in this population. Notably, we are the first to use direct, intraneural recordings of muscle sympathetic nerve activity (MSNA), the gold‐standard technique for measuring sympathetic nerve impulses in humans, to demonstrate higher SNS activity in CKD patients with non‐dipping BP patterns. In terms of Black race, while we agree that our results may not be generalizable to White patients or other races, we feel that it was important to study Black adults with CKD, an understudied patient population that has a disproportionately higher rate of kidney disease in the United States (Centers for Disease Control & Prevention, 2019).
  • Publisher: United States: John Wiley & Sons, Inc
  • Language: English
  • Identifier: EISSN: 2051-817X
    DOI: 10.14814/phy2.14674
    PMID: 33356009
  • Source: MEDLINE
    PubMed Central
    Wiley Online Library Open Access
    ProQuest Central
    DOAJ Directory of Open Access Journals
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