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17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model

ASN neuro, 2021, Vol.13, p.17590914211038443-17590914211038443 [Peer Reviewed Journal]

The Author(s) 2021 ;The Author(s) 2021. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 2021 SAGE Publications ;ISSN: 1759-0914 ;EISSN: 1759-0914 ;DOI: 10.1177/17590914211038443 ;PMID: 34491125

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Title:
17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model
Author: Xiao, Han ; Liu, Jianyang ; He, Jialin ; Lan, Ziwei ; Deng, Mingyang ; Hu, Zhiping
Subjects: 1-Phosphatidylinositol 3-kinase ; 17β-Estradiol ; AKT protein ; Animal models ; Animals ; Blood-Brain Barrier ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Injuries ; Brain injury ; Cerebral Hemorrhage - complications ; Cerebral Hemorrhage - drug therapy ; Disease Models, Animal ; Edema ; Estradiol ; Estrogens ; Extravasation ; Female ; Hemorrhage ; Mice ; Neurological diseases ; Neuroprotection ; Nuclear Receptor Coactivator 3 ; Original Paper ; Ovariectomy ; Oxidative Stress ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Signal Transduction ; Traumatic brain injury ; Water content ; Zonula occludens-1 protein
Is Part Of: ASN neuro, 2021, Vol.13, p.17590914211038443-17590914211038443
Description: Estrogen is neuroprotective in brain injury models, and steroid receptor cofactor 3 (SRC3) mediates estrogen signaling. We aimed to investigate whether and how SRC3 is involved in the neuroprotective effects of 17ß-estradiol (E2) in a mouse model of intracerebral hemorrhage (ICH). Ovariectomized female mice were treated with E2 after autologous blood injection-induced ICH. Brain damage was assessed by neurological deficit score, brain water content, and oxidative stress levels. Blood–brain barrier (BBB) integrity was evaluated by Evan's blue extravasation and claudin-5, ZO-1, and occludin levels. SRC3 expression and PI3K/Akt signaling pathway were examined in ICH mice treated with E2. The effect of SRC3 on E2-mediated neuroprotection was determined by examining neurological outcomes in SRC3-deficient mice undergone ICH and E2 treatment. We found that E2 alleviated ICH-induced brain edema and neurological deficits, protected BBB integrity, and suppressed oxidative stress. E2 enhanced SRC3 expression and PI3K-/Akt signaling pathway. SRC3 deficiency abolished the protective effects of E2 on ICH-induced neurological deficits, brain edema, and BBB integrity. Our results suggest that E2 suppresses ICH-induced brain injury and SRC3 plays a critical role in E2-mediated neuroprotection.
Publisher: Los Angeles, CA: SAGE Publications
Language: English
Identifier: ISSN: 1759-0914
EISSN: 1759-0914
DOI: 10.1177/17590914211038443
PMID: 34491125
Source: SAGE Open Access Journals
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood–Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model

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