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MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

eLife, 2016-02, Vol.5 [Peer Reviewed Journal]

2016, Zhang et al. This work is licensed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/3.0/ ) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016, Zhang et al 2016 Zhang et al ;ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/elife.11324 ;PMID: 26883496

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Title:
MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex
Author: Zhang, Wei ; Kim, Paul Jong ; Chen, Zhongcan ; Lokman, Hidayat ; Qiu, Lifeng ; Zhang, Ke ; Rozen, Steven George ; Tan, Eng King ; Je, Hyunsoo Shawn ; Zeng, Li
Subjects: Animals ; Autism ; Brain research ; Cell Cycle Proteins - metabolism ; Cell Differentiation ; Cell division ; Cell Proliferation ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cortex ; Developmental Biology and Stem Cells ; Gene expression ; Gene Expression Regulation ; Hybridization ; Immunoglobulins ; Medical research ; Mice, Inbred C57BL ; MicroRNAs - metabolism ; miR-128 ; miRNA ; neocortex ; Neural stem cells ; Neural Stem Cells - cytology ; Neural Stem Cells - physiology ; Neurogenesis ; neuronal precursor cells ; Neuroscience ; Neurosciences ; pericentriolar material 1 ; Stem cells
Is Part Of: eLife, 2016-02, Vol.5
Description: During the development, tight regulation of the expansion of neural progenitor cells (NPCs) and their differentiation into neurons is crucial for normal cortical formation and function. In this study, we demonstrate that microRNA (miR)-128 regulates the proliferation and differentiation of NPCs by repressing pericentriolar material 1 (PCM1). Specifically, overexpression of miR-128 reduced NPC proliferation but promoted NPC differentiation into neurons both in vivo and in vitro. In contrast, the reduction of endogenous miR-128 elicited the opposite effects. Overexpression of miR-128 suppressed the translation of PCM1, and knockdown of endogenous PCM1 phenocopied the observed effects of miR-128 overexpression. Furthermore, concomitant overexpression of PCM1 and miR-128 in NPCs rescued the phenotype associated with miR-128 overexpression, enhancing neurogenesis but inhibiting proliferation, both in vitro and in utero. Taken together, these results demonstrate a novel mechanism by which miR-128 regulates the proliferation and differentiation of NPCs in the developing neocortex.
Publisher: England: eLife Sciences Publications Ltd
Language: English
Identifier: ISSN: 2050-084X
EISSN: 2050-084X
DOI: 10.7554/elife.11324
PMID: 26883496
Source: AUTh Library subscriptions: ProQuest Central
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MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

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