Language:

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

Cell reports (Cambridge), 2020-02, Vol.30 (6), p.1670-1681.e7 [Peer Reviewed Journal]

2020 The Author(s) ;Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2020.01.058 ;PMID: 32049001

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
NAD+ Repletion Rescues Female Fertility during Reproductive Aging
Author: Bertoldo, Michael J. ; Listijono, Dave R. ; Ho, Wing-Hong Jonathan ; Riepsamen, Angelique H. ; Goss, Dale M. ; Richani, Dulama ; Jin, Xing L. ; Mahbub, Saabah ; Campbell, Jared M. ; Habibalahi, Abbas ; Loh, Wei-Guo Nicholas ; Youngson, Neil A. ; Maniam, Jayanthi ; Wong, Ashley S.A. ; Selesniemi, Kaisa ; Bustamante, Sonia ; Li, Catherine ; Zhao, Yiqing ; Marinova, Maria B. ; Kim, Lynn-Jee ; Lau, Laurin ; Wu, Rachael M. ; Mikolaizak, A. Stefanie ; Araki, Toshiyuki ; Le Couteur, David G. ; Turner, Nigel ; Morris, Margaret J. ; Walters, Kirsty A. ; Goldys, Ewa ; O’Neill, Christopher ; Gilchrist, Robert B. ; Sinclair, David A. ; Homer, Hayden A. ; Wu, Lindsay E.
Subjects: Aging ; Animals ; embryo development ; Female ; female fertility ; Fertility - genetics ; in vitro fertilization ; infertility ; Mice ; Mice, Transgenic ; NAD - metabolism ; nicotinamide adenine dinucleotide (NAD+) ; nicotinamide mononucleotide (NMN) ; oocyte ; reproductive aging ; SIRT2
Is Part Of: Cell reports (Cambridge), 2020-02, Vol.30 (6), p.1670-1681.e7
Description: Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals. [Display omitted] •Declining NAD(P)H is associated with oocyte dysfunction during reproductive aging•Oocyte quality and fertility can be restored by NMN treatment in aged mice•Supplementation of embryo media with NMN improves developmental milestones•SIRT2 overexpression mimics benefits of NMN but is unlikely to mediate its effects Declining oocyte quality is considered an irreversible feature of aging and is rate limiting for human fertility. Bertoldo et al. show that reversing an age-dependent decline in NAD(P)H restores oocyte quality, embryo development, and functional fertility in aged mice. These findings may be relevant to reproductive medicine.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 2211-1247
EISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.01.058
PMID: 32049001
Source: GFMER Free Medical Journals
MEDLINE
Open Access: Cell Press Free Archives
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

2020 The Author(s) ;Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. ;ISSN: 2211-1247 ;EISSN: 2211-1247 ;DOI: 10.1016/j.celrep.2020.01.058 ;PMID: 32049001

Searching Remote Databases, Please Wait