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Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool

Frontiers in psychiatry, 2023-01, Vol.14, p.1061284-1061284 [Peer Reviewed Journal]

Copyright © 2023 Tran, Nguyen, Boyer, Fond, Auquier, Nguyen, Tran, Nguyen, Choi, Le, Latkin, Nathan, Husain, McIntyre, Ho, Zhang and Ho. ;Copyright © 2023 Tran, Nguyen, Boyer, Fond, Auquier, Nguyen, Tran, Nguyen, Choi, Le, Latkin, Nathan, Husain, McIntyre, Ho, Zhang and Ho. 2023 Tran, Nguyen, Boyer, Fond, Auquier, Nguyen, Tran, Nguyen, Choi, Le, Latkin, Nathan, Husain, McIntyre, Ho, Zhang and Ho ;ISSN: 1664-0640 ;EISSN: 1664-0640 ;DOI: 10.3389/fpsyt.2023.1061284 ;PMID: 36778640

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  • Title:
    Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool
  • Author: Tran, Bach Xuan ; Nguyen, Tham Thi ; Boyer, Laurent ; Fond, Guillaume ; Auquier, Pascal ; Nguyen, Hao Si Anh ; Tran, Ha Thi Nhi ; Nguyen, Hung Manh ; Choi, Jongkwan ; Le, Huong Thi ; Latkin, Carl A ; Nathan, Kalpana Isabel ; Husain, Syeda F ; McIntyre, Roger S ; Ho, Cyrus S H ; Zhang, Melvyn W B ; Ho, Roger C M
  • Subjects: cortical hemodynamic response ; near-infrared ; NIR spectroscopy ; Psychiatry ; schizophrenia ; spectrometry ; Vietnam
  • Is Part Of: Frontiers in psychiatry, 2023-01, Vol.14, p.1061284-1061284
  • Description: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. One hundred fifty-seven participants were divided into schizophrenia ( = 110) and healthy controls group ( = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO ) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area. People with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731-0.872). The Youden's index reached a peak (0.57) at the optimal cut-point value (HbO cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%. Assessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1664-0640
    EISSN: 1664-0640
    DOI: 10.3389/fpsyt.2023.1061284
    PMID: 36778640
  • Source: DOAJ : Directory of Open Access Journals
    Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central (PMC)
    ROAD: Directory of Open Access Scholarly Resources
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