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Graphene sheet-based electrochemical sensor with cationic surfactant for sensitive detection of atorvastatin

Sensors international, 2022, Vol.3, p.100198, Article 100198 [Peer Reviewed Journal]

2022 The Authors ;ISSN: 2666-3511 ;EISSN: 2666-3511 ;DOI: 10.1016/j.sintl.2022.100198

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  • Title:
    Graphene sheet-based electrochemical sensor with cationic surfactant for sensitive detection of atorvastatin
  • Author: Patil, Vinoda B. ; Malode, Shweta J. ; Tuwar, Suresh M. ; Shetti, Nagaraj P.
  • Subjects: Atorvastatin ; Cetyltrimethylammonium bromide ; Graphene ; Limit of detection ; Voltammetry techniques
  • Is Part Of: Sensors international, 2022, Vol.3, p.100198, Article 100198
  • Description: The present work investigates the electrochemical studies of atorvastatin (ATRV) by establishing graphene (GR) and cationic surfactant cetyltrimethylammonium bromide (CTAB) based electrochemical sensor (GR-CTAB/CPE). The morphological study of a modifier was executed utilizing the electronic scanning microscopy (SEM) technique. GR-CTAB/CPE was identified as a supersensitive electrode for the identification of ATRV, as the electrochemical sensor exhibited enhanced electrocatalytic property and increased peak current in pH 4.2 of phosphate buffer solution employing voltammetric approaches like cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The impact of pre-concentration time, supporting electrolyte (pH), scan rate, and concentration was examined. The number of protons and electrons involved in the electro-oxidative mechanism of ATRV was depicted. The ATRV at the developed sensor has a limit of detection of 2.46 ​× ​10−9 ​M. The proposed method was proven effective in determining ATRV concentration in clinical and biological samples. The data obtained from the recovery studies suggests that the GR-CTAB/CPE was selective and highly sensible in identifying ATRV. [Display omitted] •Developed GR-CTAB/CPE to investigate electro-oxidation of ATRV.•The electro-oxidation process was controlled by adsorption with two electrons and a single proton transfer.•The detection limit was calculated and found to be 2.46 nM.•The fabricated electrochemical sensor was employed to investigate ATRV in clinical and biological samples.
  • Publisher: Elsevier B.V
  • Language: English
  • Identifier: ISSN: 2666-3511
    EISSN: 2666-3511
    DOI: 10.1016/j.sintl.2022.100198
  • Source: DOAJ Directory of Open Access Journals
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