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Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Materials research (São Carlos, São Paulo, Brazil), 2016-02, Vol.19 (1), p.106-116 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 1516-1439 ;ISSN: 1980-5373 ;EISSN: 1980-5373 ;DOI: 10.1590/1980-5373-MR-2015-0249

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Title:
Bacterial Cellulose/Collagen Hydrogel for Wound Healing
Author: Moraes, Paula Rodrigues Fontes de Sousa ; Saska, Sybele ; Barud, Hernane ; de Lima, Lais Roncalho ; Martins, Virginia da Conceicao Amaro ; Plepis, Ana Maria de Guzzi ; Ribeiro, Sidney Jose Lima ; Gaspar, Ana Maria Minarelli
Subjects: Bacteria ; bacterial cellulose ; Cellulose ; collagen ; Collagens ; Dressing ; ENGINEERING, CHEMICAL ; hydrogel ; Hydrogels ; Infrared spectroscopy ; MATERIALS SCIENCE, MULTIDISCIPLINARY ; METALLURGY & METALLURGICAL ENGINEERING ; Ointment ; tissue repair ; wound dressing ; Wound healing
Is Part Of: Materials research (São Carlos, São Paulo, Brazil), 2016-02, Vol.19 (1), p.106-116
Description: This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed - Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.
Publisher: ABM, ABC, ABPol
Language: English;Portuguese;Spanish
Identifier: ISSN: 1516-1439
ISSN: 1980-5373
EISSN: 1980-5373
DOI: 10.1590/1980-5373-MR-2015-0249
Source: Freely Accessible Journals
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Bacterial Cellulose/Collagen Hydrogel for Wound Healing

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 1516-1439 ;ISSN: 1980-5373 ;EISSN: 1980-5373 ;DOI: 10.1590/1980-5373-MR-2015-0249

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