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The role of linoleic acid in oxidative damage of hemoglobin due to cytomegelavirus infection during pregnancy

Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny, 2019-10, Vol.18 (3), p.15-20 [Peer Reviewed Journal]

ISSN: 1682-0363 ;EISSN: 1819-3684 ;DOI: 10.20538/1682-0363-2019-3-15-20

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  • Title:
    The role of linoleic acid in oxidative damage of hemoglobin due to cytomegelavirus infection during pregnancy
  • Author: Andrievskaya, I. A. ; Ishutina, N. A.
  • Subjects: беременность ; гемоглобин ; линолевая кислота ; окислительный стресс ; цитомегаловирусная инфекция
  • Is Part Of: Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny, 2019-10, Vol.18 (3), p.15-20
  • Description: The goal is to study the mechanisms of linoleic acid-dependent oxidative damage to hemoglobin in blood erythrocytes of pregnant women with cytomegalovirus (CMV) infection during the first trimester. Materials and methods . The study included 55 CMV-seropositive pregnant women at 8–11 weeks pregnant, aged 24,7 ± 0,18 years. 20 women had exacerbated cytomegalovirus infection and in 35 women a latent course of the disease was observed. The control group consisted of 20 CMV-seronegative pregnant women, comparable in age and gestational age with the group of pregnant women with cytomegalovirus infection. The levels of linoleic acid, superoxide dismutase, glutathione peroxidase and methemoglobin in the blood were studied by the spectrophotometry. Glutathione was determined by histochemical methods, the total amount of hemoglobin was measured using the automatic hematological analyzer, and hydrogen peroxide level was calculated by enzyme immunoassay. Results . In cytomegalovirus infection, an increase in the indices of exogenous hydrogen peroxide and linoleic acid in blood erythrocytes of pregnant women is observed. During the period of acute disease in the first trimester of pregnancy it causes oxidative modification and a decrease in the level of not only superoxide dismutase, glutathione peroxidase and glutathione, the processes involved in the redox regulation of thiol-disulfide exchange of erythrocytes, but also hemoglobin with formation of large amount of methemoglobin, which contributes to reduction of oxygen metabolism and development of hemic hypoxia. In the latent course of the disease, the oxidative damage to hemoglobin in the erythrocytes of pregnant women is mitigated by the increase in the activity of redox enzymes, which maintains oxygen homeostasis at the level necessary for the development of pregnancy. 
  • Publisher: Siberian State Medical University (Tomsk)
  • Language: English
  • Identifier: ISSN: 1682-0363
    EISSN: 1819-3684
    DOI: 10.20538/1682-0363-2019-3-15-20
  • Source: ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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