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Poxvirus viability and signatures in historical relics

Emerging infectious diseases, 2014-02, Vol.20 (2), p.177-184 [Peer Reviewed Journal]

COPYRIGHT 2014 U.S. National Center for Infectious Diseases ;COPYRIGHT 2014 U.S. National Center for Infectious Diseases ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2002.131098 ;PMID: 24447382

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Title:
Poxvirus viability and signatures in historical relics
Author: McCollum, Andrea M ; Li, Yu ; Wilkins, Kimberly ; Karem, Kevin L ; Davidson, Whitni B ; Paddock, Christopher D ; Reynolds, Mary G ; Damon, Inger K
Subjects: Autopsy ; Cadaver ; DNA viruses ; DNA, Viral - isolation & purification ; Dosage and administration ; Health aspects ; History ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, Ancient ; Humans ; Microbial Viability ; orthopoxvirus ; poxvirus ; Smallpox ; Smallpox - history ; Smallpox - prevention & control ; Smallpox - transmission ; Smallpox - virology ; Smallpox vaccine ; Smallpox Vaccine - immunology ; smallpox virus ; Specimen Handling - methods ; Vaccination ; Vaccinia virus - immunology ; variola ; Variola virus - isolation & purification ; Variola virus - pathogenicity ; Variola virus - physiology ; viruses
Is Part Of: Emerging infectious diseases, 2014-02, Vol.20 (2), p.177-184
Description: Although it has been >30 years since the eradication of smallpox, the unearthing of well-preserved tissue material in which the virus may reside has called into question the viability of variola virus decades or centuries after its original occurrence. Experimental data to address the long-term stability and viability of the virus are limited. There are several instances of well-preserved corpses and tissues that have been examined for poxvirus viability and viral DNA. These historical specimens cause concern for potential exposures, and each situation should be approached cautiously and independently with the available information. Nevertheless, these specimens provide information on the history of a major disease and vaccination against it.
Publisher: United States: U.S. National Center for Infectious Diseases
Language: English
Identifier: ISSN: 1080-6040
EISSN: 1080-6059
DOI: 10.3201/eid2002.131098
PMID: 24447382
Source: Centers for Disease Control and Prevention
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Poxvirus viability and signatures in historical relics

COPYRIGHT 2014 U.S. National Center for Infectious Diseases ;COPYRIGHT 2014 U.S. National Center for Infectious Diseases ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2002.131098 ;PMID: 24447382

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