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Structure, function, and genetics of lipoprotein (a)

Journal of lipid research, 2016-08, Vol.57 (8), p.1339-1359 [Peer Reviewed Journal]

2016 © 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. ;Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc. ;Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc. 2016 ;ISSN: 0022-2275 ;EISSN: 1539-7262 ;DOI: 10.1194/jlr.R067314 ;PMID: 27074913

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Title:
Structure, function, and genetics of lipoprotein (a)
Author: Schmidt, Konrad ; Noureen, Asma ; Kronenberg, Florian ; Utermann, Gerd
Subjects: Animals ; Cardiovascular Diseases - genetics ; cardiovascular risk factor ; copy number variation ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; lipoprotein metabolism ; Lipoprotein(a) - chemistry ; Lipoprotein(a) - physiology ; Mendelian randomization ; Polymorphism, Genetic ; Protein Domains ; Thematic Review Series
Is Part Of: Journal of lipid research, 2016-08, Vol.57 (8), p.1339-1359
Description: Lipoprotein (a) [Lp(a)] has attracted the interest of researchers and physicians due to its intriguing properties, including an intragenic multiallelic copy number variation in the LPA gene and the strong association with coronary heart disease (CHD). This review summarizes present knowledge of the structure, function, and genetics of Lp(a) with emphasis on the molecular and population genetics of the Lp(a)/LPA trait, as well as aspects of genetic epidemiology. It highlights the role of genetics in establishing Lp(a) as a risk factor for CHD, but also discusses uncertainties, controversies, and lack of knowledge on several aspects of the genetic Lp(a) trait, not least its function.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0022-2275
EISSN: 1539-7262
DOI: 10.1194/jlr.R067314
PMID: 27074913
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
DOAJ Directory of Open Access Journals

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Structure, function, and genetics of lipoprotein (a)

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