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BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study

Translational psychiatry, 2023-07, Vol.13 (1), p.251-251, Article 251 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 ;ISSN: 2158-3188 ;EISSN: 2158-3188 ;DOI: 10.1038/s41398-023-02539-7 ;PMID: 37433779

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  • Title:
    BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study
  • Author: O'Loughlin, Jessica ; Casanova, Francesco ; Hughes, Amanda ; Fairhurst-Hunter, Zammy ; Li, Liming ; Chen, Zhengming ; Bowden, Jack ; Watkins, Ed ; Freathy, Rachel M ; Howe, Laura D ; Walters, Robin G ; Tyrrell, Jessica
  • Subjects: Adult ; Biobanks ; Body Mass Index ; China ; East Asian People ; European People ; Female ; Health Status ; Humans ; Male
  • Is Part Of: Translational psychiatry, 2023-07, Vol.13 (1), p.251-251, Article 251
  • Description: Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations is limited. Here, we investigated the association between BMI and well-being in people of (a) East Asian and (b) European ancestry in the China Kadoorie Biobank (CKB) and UK Biobank (UKB), respectively. Mendelian randomisation (MR) methods were used to test the relationship between BMI with (a) health satisfaction and (b) life satisfaction. One-sample MR enabled us to test effects in men and women separately and to test the role of cultural contexts by stratifying our analyses by urban and rural home location in both China and the UK. Further, we implemented a control function method to test the linearity of the BMI-well-being relationship. We found evidence of different associations between BMI and well-being in individuals of East Asian versus European ancestry. For example, a genetically instrumented higher BMI tentatively associated with higher health satisfaction in people of East Asian ancestry, especially in females (ß: 0.041, 95% CI: 0.002, 0.081). In contrast, there was a robust inverse association between higher genetically instrumented BMI and health satisfaction in all European ancestry UKB participants (ß: -0.183, 95% CI: -0.200, -0.165, P  < 1.00E-15). We also showed the importance of considering non-linear relationships in the MR framework by providing evidence of non-linear relationships between BMI and health and life satisfaction. Overall, our study suggests potential setting-specific causality in the relationship between BMI and subjective well-being, with robust differences observed between East Asians and Europeans when considering very similar outcomes. We highlight the importance of (a) considering potential non-linear relationships in causal analyses and (b) testing causal relationships in different populations, as the casual nature of relationships, especially relationships influenced by social processes, may be setting-specific.
  • Publisher: United States: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2158-3188
    EISSN: 2158-3188
    DOI: 10.1038/s41398-023-02539-7
    PMID: 37433779
  • Source: Open Access: Nature Open Access
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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