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Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field

International journal of molecular sciences, 2016-06, Vol.17 (6), p.986-986 [Peer Reviewed Journal]

Copyright MDPI AG 2016 ;2016 by the authors; licensee MDPI, Basel, Switzerland. 2016 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms17060986 ;PMID: 27338370

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Title:
Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field
Author: Liu, Chao ; Sun, Yonghai ; Mao, Qian ; Guo, Xiaolei ; Li, Peng ; Liu, Yang ; Xu, Na
Subjects: anti-proliferating activity ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Ascomycota - chemistry ; Ascomycota - growth & development ; Cancer ; Carbohydrates ; Cell growth ; Chemical Fractionation - methods ; chemical structure ; Electric fields ; Electrochemical Techniques - methods ; Fermentation ; Fungal Polysaccharides - chemistry ; Fungal Polysaccharides - pharmacology ; HT29 Cells ; Humans ; Morchella esculenta ; Mushrooms ; polysaccharide ; pulsed electric field
Is Part Of: International journal of molecular sciences, 2016-06, Vol.17 (6), p.986-986
Description: Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged fermentation. The endo-polysaccharide was separated and purified by column chromatography and Gel permeation chromatography, and analyzed by gas chromatography. The MEP with an average molecular weight of 81,835 Da consisted of xylose, glucose, mannose, rhamnose and galactose at the ratio of 5.4:5.0:6.5:7.8:72.3. Structure of MEP was further analyzed by Fourier-transform infrared spectroscopy and ¹H and (13)C liquid-state nuclear magnetic resonance spectroscopy. Apoptosis tests proved that MEP could inhibit the proliferation and growth of human colon cancer HT-29 cells in a time- and dose-dependent manner within 48 h. This study provides more information on chemical structure of anti-proliferating polysaccharides isolated from Morchella esculenta.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms17060986
PMID: 27338370
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field

Copyright MDPI AG 2016 ;2016 by the authors; licensee MDPI, Basel, Switzerland. 2016 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms17060986 ;PMID: 27338370

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