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Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy

Frontiers in physiology, 2018-11, Vol.9, p.1500-1500 [Peer Reviewed Journal]

COPYRIGHT 2018 Frontiers Research Foundation ;info:eu-repo/semantics/openAccess ;Copyright © 2018 Skogestad and Aronsen. 2018 Skogestad and Aronsen ;ISSN: 1664-042X ;EISSN: 1664-042X ;DOI: 10.3389/fphys.2018.01500 ;PMID: 30464746

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  • Title:
    Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
  • Author: Skogestad, Jonas ; Aronsen, Jan Magnus
  • Subjects: Arrhythmia ; arrhythmia (heart rhythm disorders) ; calcium ; Complications and side effects ; heart failure ; hypokalaemia ; Hypokalemia ; Na+ - K+-ATPase ; Physiology ; Risk factors
  • Is Part Of: Frontiers in physiology, 2018-11, Vol.9, p.1500-1500
  • Description: Routine use of diuretics and neurohumoral activation make hypokalemia (serum K < 3. 5 mM) a prevalent electrolyte disorder among heart failure patients, contributing to the increased risk of ventricular arrhythmias and sudden cardiac death in heart failure. Recent experimental studies have suggested that hypokalemia-induced arrhythmias are initiated by the reduced activity of the Na /K -ATPase (NKA), subsequently leading to Ca overload, Ca /Calmodulin-dependent kinase II (CaMKII) activation, and development of afterdepolarizations. In this article, we review the current mechanistic evidence of hypokalemia-induced triggered arrhythmias and discuss how molecular changes in heart failure might lower the threshold for these arrhythmias. Finally, we discuss how recent insights into hypokalemia-induced arrhythmias could have potential implications for future antiarrhythmic treatment strategies.
  • Publisher: Switzerland: Frontiers Research Foundation
  • Language: English;Norwegian
  • Identifier: ISSN: 1664-042X
    EISSN: 1664-042X
    DOI: 10.3389/fphys.2018.01500
    PMID: 30464746
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    NORA Norwegian Open Research Archives
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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