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Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model

Brazilian journal of biology, 2023, Vol.83, p.e237412-10 [Peer Reviewed Journal]

2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 1519-6984 ;ISSN: 1678-4375 ;EISSN: 1678-4375 ;DOI: 10.1590/1519-6984.237412 ;PMID: 35081234

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  • Title:
    Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model
  • Author: Dal Pai, J ; da Silva, J C ; Sanabria, V ; Amorim, R P ; Predebon, G ; Cossa, A C ; Trindade-Filho, E ; Amado, D
  • Subjects: Animal behavior ; Animals ; Behavior ; BIOLOGY ; Brain research ; Convulsions & seizures ; Epilepsy ; Excitability ; experimental model ; Experimental research ; Female ; female rats ; Females ; Head movement ; Hormones ; Models, Theoretical ; Muscarinic Agonists - toxicity ; non-Status Epilepticus ; Pilocarpine ; Pilocarpine - toxicity ; Rats ; Rats, Wistar ; Rhythms ; Rodents ; Seizures ; Seizures - chemically induced ; Status Epilepticus - chemically induced ; Tornadoes ; video monitoring
  • Is Part Of: Brazilian journal of biology, 2023, Vol.83, p.e237412-10
  • Description: Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase. Previews works observed mossy fiber sprouting in the hippocampus of Non-SE (NSE) rats, while others observed spontaneous and recurrent seizures (SRS) 6 - 8 months after animals received Pilo. It is known that neuronal excitability is influenced by female hormones, as well as, the occurrence of SE in castrated and non-castrated female rats. However, it is not known whether females that received Pilo and did not show SE, may have SRS. The aim of this work was to investigate whether castrated and non-castrated female rats that did not show behavioral SE after Pilo, will develop SRS in the following one-year. For that, animals received 360 mg/kg of Pilo and were video monitored for 12 months. SE females from castrated and non-castrated groups became epileptic since the first month after drug injection. Epileptic behaviors were identified watching video monitoring recordings in the fast speed. Castrated and Non-castrated NSE animals showed behaviors resembling seizures described by Racine Scale stages 1 - 3. Motor alterations showed by NSE groups could be observed only when recordings were analyzed in slow speed. In addition, behavioral manifestations as, rhythmic head movements, sudden head movements, whole body movements and immobility were also observed in both, SE and NSE groups. We concluded that NSE female rats may have become epileptic. Adding to it, slow speed analysis of motor alterations was essential for the observation of NSE findings, which suggests that possibly many motor alterations have been underestimated in epilepsy experimental research.
  • Publisher: Brazil: Instituto Internacional de Ecologia
  • Language: English;Portuguese
  • Identifier: ISSN: 1519-6984
    ISSN: 1678-4375
    EISSN: 1678-4375
    DOI: 10.1590/1519-6984.237412
    PMID: 35081234
  • Source: SciELO
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    ProQuest Central
    DOAJ Directory of Open Access Journals
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