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Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study

Journal of advanced pharmaceutical technology and research, 2018-07, Vol.9 (3), p.113-118 [Peer Reviewed Journal]

COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd. ;2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright: © 2018 Journal of Advanced Pharmaceutical Technology & Research 2018 ;ISSN: 2231-4040 ;EISSN: 0976-2094 ;DOI: 10.4103/japtr.JAPTR_298_18 ;PMID: 30338238

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  • Title:
    Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study
  • Author: Al-Naimi, Marwa ; Hussien, Nawar ; Rasheed, Huda ; Al-kuraishy, Hayder ; Al-Gareeb, Ali
  • Subjects: Antioxidants ; Antioxidants (Nutrients) ; Blood pressure ; Body mass index ; Cardiovascular disease ; Care and treatment ; Free radicals ; Hypothyroidism ; Levothyroxine ; Lipid peroxidation ; Lipids ; Metabolism ; Original ; Oxidative stress ; Paraoxonase ; Paraoxonase 1 ; PON-1 ; Serum levels ; Thyroid ; Thyroid gland ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; Triiodothyronine
  • Is Part Of: Journal of advanced pharmaceutical technology and research, 2018-07, Vol.9 (3), p.113-118
  • Description: Primary hypothyroidism is associated with oxidative stress and insufficient antioxidant capacity. This study was conducted to evaluate the effects of levothyroxine replacement therapy on paraoxonase 1 (PON-1) serum levels in a patients with primary hypothyroidism. Thirty-one patients with primary hypothyroidism compared to 20 healthy controls were recruited from. A venous blood sample were taken after an overnight fasting for biochemical parameters, before and after starting levothyroxine therapy (100 μ g/day) for 3 months duration. The biochemical variables were PON-1 serum levels, lipid profiles, triiodothyronine (T3), thyroxin (T4), and thyroid stimulating hormone (TSH) serum levels. Levothyroxine replacement therapy leads to a significant amelioration of thyroid functions, lipid profile, cardiometabolic measures P < 0.05 in patients with primary hypothyroidism. Levothyroxine leads to significant elevation in PON-1 serum levels from 188.42 ± 19.81 (U/mL) to 361.23 ± 33.62 (U/mL) P < 0.0001. This study concluded that levothyroxine replacement therapy significantly increases PON-1 serum levels in patients with primary hypothyroidism and attenuating hypothyroidism-induced oxidative stress.
  • Publisher: India: Wolters Kluwer India Pvt. Ltd
  • Language: English
  • Identifier: ISSN: 2231-4040
    EISSN: 0976-2094
    DOI: 10.4103/japtr.JAPTR_298_18
    PMID: 30338238
  • Source: GFMER Free Medical Journals
    PubMed Central
    Medknow Open Access Medical Journals
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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