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Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes

BMC medicine, 2017-07, Vol.15 (1), p.131-131, Article 131 [Peer Reviewed Journal]

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;Copyright BioMed Central 2017 ;The Author(s). 2017 ;ISSN: 1741-7015 ;EISSN: 1741-7015 ;DOI: 10.1186/s12916-017-0901-x ;PMID: 28720102

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Title:
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Author: Kolb, Hubert ; Martin, Stephan
Subjects: Aging ; Autophagy ; Body mass ; Body Mass Index ; Carbohydrates ; Cardiovascular disease ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - prevention & control ; Diabetes prevention ; Diabetes risk factors ; Diet ; Disease control ; Disease prevention ; DNA methylation ; Environment ; Exercise ; Feeding Behavior ; Food ; Gastrointestinal surgery ; Health risks ; Heart surgery ; Humans ; Incidence ; Insulin resistance ; Life Style ; Lifestyle ; Lifestyles ; Mental depression ; Metabolism ; Noise ; Obesity ; Pathogenesis ; Physical activity ; Prevention ; Review ; Risk ; Risk Factors ; Sleep ; Smoking ; Socioeconomics ; Type 2 diabetes ; Weight control
Is Part Of: BMC medicine, 2017-07, Vol.15 (1), p.131-131, Article 131
Description: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades. In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status. In general, these factors promote an increase in body mass index. Since loss of β-cell function is the ultimate cause of developing overt type 2 diabetes, environmental and lifestyle changes must have resulted in a higher risk of β-cell damage in those at genetic risk. Multiple mechanistic pathways may come into play. Strategies of diabetes prevention should aim at promoting a 'diabetes-protective lifestyle' whilst simultaneously enhancing the resistance of the human organism to pro-diabetic environmental and lifestyle factors. More research on diabetes-protective mechanisms seems warranted.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1741-7015
EISSN: 1741-7015
DOI: 10.1186/s12916-017-0901-x
PMID: 28720102
Source: SpringerOpen
PubMed Central (Open access)
DOAJ Directory of Open Access Journals
Geneva Foundation Free Medical Journals at publisher websites
ROAD
MEDLINE
ProQuest Central

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Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes

COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;Copyright BioMed Central 2017 ;The Author(s). 2017 ;ISSN: 1741-7015 ;EISSN: 1741-7015 ;DOI: 10.1186/s12916-017-0901-x ;PMID: 28720102

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