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Functionalized corn stalk carboxymethyl cellulose and mesoporous silica SBA-15 composite hydrogel-immobilized lipase for the resolution of racemic ibuprofen ethyl ester

Green chemistry letters and reviews, 2024-12, Vol.17 (1) [Peer Reviewed Journal]

ISSN: 1751-8253 ;EISSN: 1751-7192 ;DOI: 10.1080/17518253.2024.2338241

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  • Title:
    Functionalized corn stalk carboxymethyl cellulose and mesoporous silica SBA-15 composite hydrogel-immobilized lipase for the resolution of racemic ibuprofen ethyl ester
  • Author: Hong Zhang ; Wenbin Liu ; Lei Wang ; Xin Zhang ; Bo Wang ; Xu Zeng ; Bin Zhang
  • Subjects: enantioselective biocatalyst ; green synthesis ; hydrogel composites ; Lipase immobilization
  • Is Part Of: Green chemistry letters and reviews, 2024-12, Vol.17 (1)
  • Description: ABSTRACTThe immobilization of enzymes is an important strategy to improve their stability and reusability. However, it often comes with a trade off of reduced biological activity and catalytic efficiency. In this study, a composite hydrogel based on corn stalk carboxymethyl cellulose, acrylic acid, and mesoporous silica SBA-15 was developed as a support for the immobilization of lipase from Pseudomonas S.P. (PSL). The surface morphology and functional properties of the composite hydrogels were investigated by scanning electron microscopy, Fourier transform infrared, X-ray diffraction and simultaneous thermal analyzer, respectively. The composite hydrogel materials had a large number of mesopores and macropores were present in the wall of the hydrogel sheet. The hydrogel had a network structure that reduced the diffusion resistance of the substrate and improved the accessibility of the enzyme. The immobilized PSL exhibited high enantioselectivity (E value: 88.2) and enzyme activity (316.8 µmol/g/min) in the preparation of (S)-ibuprofen by enzymatic hydrolytic resolution of racemic ibuprofen ethyl ester. This prepared novel composite hydrogel is a promising supporting matrix for the immobilization of enzymes.
  • Publisher: Taylor & Francis Group
  • Language: English
  • Identifier: ISSN: 1751-8253
    EISSN: 1751-7192
    DOI: 10.1080/17518253.2024.2338241
  • Source: Taylor & Francis Open Access
    Alma/SFX Local Collection
    ProQuest Central
    DOAJ Directory of Open Access Journals
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