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Analysis of the autoimmune response to BP180 in Chinese stroke patients

Anais brasileiros de dermatología, 2023-01, Vol.98 (1), p.13-16 [Peer Reviewed Journal]

2022 Sociedade Brasileira de Dermatologia ;Copyright © 2022 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved. ;2022 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. 2022 Sociedade Brasileira de Dermatologia ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0365-0596 ;ISSN: 1806-4841 ;EISSN: 1806-4841 ;DOI: 10.1016/j.abd.2022.01.012 ;PMID: 36456305

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  • Title:
    Analysis of the autoimmune response to BP180 in Chinese stroke patients
  • Author: Wang, Jing ; Liu, Hong ; Wang, Zhenzhen ; Pan, Qing ; Zhang, Furen
  • Subjects: Antibodies ; Autoantibodies ; Autoantigens ; Autoimmunity ; Bullous pemphigoid ; Collagen Type XVII ; DERMATOLOGY ; East Asian People ; Enzyme-Linked Immunosorbent Assay ; Humans ; Non-Fibrillar Collagens ; Original ; Pemphigoid, Bullous - pathology ; Stroke
  • Is Part Of: Anais brasileiros de dermatología, 2023-01, Vol.98 (1), p.13-16
  • Description: Significant association between bullous pemphigoid (BP) and stroke has been reported. This study aimed to evaluate the level of anti-BP180 antibody in stroke patients to explore the relationship between BP and stroke in their pathogenesis. We collected serum samples from stroke patients and matched controls between February 2019 and June 2020. The anti-BP180 antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). A total of 1183 stroke patients including 970 with cerebral infarction (CI), 192 with intracerebral hemorrhage (ICH), 21 with CI and ICH, and 855 controls were enrolled in this study. Anti-BP180 autoantibody values were significantly higher in stroke patients than in controls (p<0.001). Anti-BP180 autoantibody-positive rates were 12.51% (148) in stroke patients and 4.68% (40) in controls (p<0.001, OR=2.65). In anti-BP180 autoantibody-positive subjects, the values were significantly higher in stroke patients than in controls (p<0.001). However, only 10 (6.76%) stroke patients and 3 (7.5%) controls had high values (> 100 RU/mL) (p=0.87). Stratified analysis showed that anti-BP180 antibody positive rates were independent of age, sex, and stroke subtypes in the stroke group. Positive rates in patients with both CI and ICH were nearly two times higher than those in patients with either CI or ICH alone (p=0.11, OR=1.94). This study had a limited sample size and lacked quantitative criteria for stroke severity. Anti-BP180 antibody values and positive rates were higher in stroke patients than in controls, suggesting that stroke patients may have higher of developing BP.
  • Publisher: Spain: Elsevier España, S.L.U
  • Language: English;Portuguese
  • Identifier: ISSN: 0365-0596
    ISSN: 1806-4841
    EISSN: 1806-4841
    DOI: 10.1016/j.abd.2022.01.012
    PMID: 36456305
  • Source: SciELO
    GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals
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