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Macrophages: friend or foe in idiopathic pulmonary fibrosis?

Respiratory research, 2018-09, Vol.19 (1), p.170-170, Article 170 [Peer Reviewed Journal]

COPYRIGHT 2018 BioMed Central Ltd. ;Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License. ;The Author(s). 2018 ;ISSN: 1465-993X ;ISSN: 1465-9921 ;EISSN: 1465-993X ;DOI: 10.1186/s12931-018-0864-2 ;PMID: 30189872

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Title:
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
Author: Zhang, Lei ; Wang, Yi ; Wu, Guorao ; Xiong, Weining ; Gu, Weikuan ; Wang, Cong-Yi
Subjects: Alternatively activated (M2) macrophages ; Alveoli ; Animals ; Care and treatment ; Classically activated (M1) macrophages ; Cytokines ; Development and progression ; Endoplasmic reticulum ; Etiology ; Fibrosis ; Gene expression ; Humans ; Idiopathic Pulmonary Fibrosis - diagnosis ; Idiopathic Pulmonary Fibrosis - immunology ; Idiopathic Pulmonary Fibrosis - metabolism ; Inflammation ; IPF ; Lung diseases ; Lungs ; Macrophage Activation - physiology ; Macrophage polarization ; Macrophages ; Macrophages - immunology ; Macrophages - metabolism ; Medical prognosis ; Microenvironments ; Pathogenesis ; Phenotypes ; Prevention ; Proteins ; Pulmonary fibrosis ; Review ; Surfactants ; Telomerase ; Therapeutic strategies ; Wound healing
Is Part Of: Respiratory research, 2018-09, Vol.19 (1), p.170-170, Article 170
Description: Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung disease of unknown etiology. Over the past decade, macrophage has been recognized to play a significant role in IPF pathogenesis. Depending on the local microenvironments, macrophages can be polarized to either classically activated (M1) or alternatively activated (M2) phenotypes. In general, M1 macrophages are responsible for wound healing after alveolar epithelial injury, while M2 macrophages are designated to resolve wound healing processes or terminate inflammatory responses in the lung. IPF is a pathological consequence resulted from altered wound healing in response to persistent lung injury. In this review, we intend to summarize the current state of knowledge regarding the process of macrophage polarization and its mediators in the pathogenesis of pulmonary fibrosis. Our goal is to update the understanding of the mechanisms underlying the initiation and progression of IPF, and by which, we expect to provide help for developing effective therapeutic strategies in clinical settings.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1465-993X
ISSN: 1465-9921
EISSN: 1465-993X
DOI: 10.1186/s12931-018-0864-2
PMID: 30189872
Source: SpringerOpen
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Macrophages: friend or foe in idiopathic pulmonary fibrosis?

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