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Drug therapy problems and contributing factors among patients with epilepsy

PloS one, 2024-03, Vol.19 (3), p.e0299968-e0299968 [Peer Reviewed Journal]

Copyright: © 2024 Niriayo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ;COPYRIGHT 2024 Public Library of Science ;2024 Niriayo et al 2024 Niriayo et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0299968 ;PMID: 38451979

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  • Title:
    Drug therapy problems and contributing factors among patients with epilepsy
  • Author: Niriayo, Yirga Legesse ; Gebregziabher, Tesfay ; Demoz, Gebre Teklemariam ; Tesfay, Nigusse ; Gidey, Kidu
  • Subjects: Adult ; Analysis ; Anticonvulsants ; Care and treatment ; Causes of ; Diagnosis ; Dosage and administration ; Drug therapy ; Drugs ; Epilepsy ; Epilepsy - chemically induced ; Epilepsy - drug therapy ; Ethiopia ; Evidence-based medicine ; Health aspects ; Hospitals ; Humans ; Medical research ; Medicine and Health Sciences ; Medicine, Experimental ; Methods ; Mortality ; Patient compliance ; Patient outcomes ; People and Places ; Phenytoin - adverse effects ; Quality of Life ; Seizures (Medicine) ; Seizures - drug therapy
  • Is Part Of: PloS one, 2024-03, Vol.19 (3), p.e0299968-e0299968
  • Description: Although antiseizure medications play a crucial role in the management of epilepsy, their benefit can be compromised due to drug-related problems. Drug therapy problems can lead to poor seizure control, reduced quality of life, and increased morbidity and mortality in patients with epilepsy. However, in our setting, there is limited knowledge about drug therapy problems and the factors that contribute to them. The aim of this study was to investigate the prevalence and contributing factors of drug-therapy problems among patients with epilepsy. A hospital-based prospective observational study was conducted at the neurologic clinic of Ayder Comprehensive Specialized Hospital, located in the Tigray region of Northern Ethiopia. The study included adult patients diagnosed with epilepsy who had been taking at least one antiseizure medication for a minimum of six months. Data were collected by conducting patient interviews and expert reviews of medical and medication records. Prior to data review and interviews, each patient provided written informed consent. Drug therapy problems were identified and classified using Cipolle's method, followed by a consensus review conducted with a panel of experts. Statistical analysis was performed using a statistical software package; SPSS version 22. Binary logistic regression analysis was conducted to determine the contributing factors of drug therapy problems. Statistical significance was determined at p<0.05. A study conducted on 250 participants revealed that 55.2% of the patients experienced one or more drug therapy problems. Our analysis identified a total of 282 drug therapy problems, with a mean of 2±0.52 drug therapy problems per patient. The most commonly observed drug therapy problems were dosage too low (30.0%), noncompliance (22%), adverse drug reaction (18%), and unnecessary drug therapy (16.4%). The commonly involved antiseizure medications in these drug therapy problems were phenytoin (22.8%), Valproic acid (20.8%), and Phenobarbital (18.4%). Furthermore, our findings revealed that combination therapy (AOR: 3.92, 95%CI: 1.19-12.97) and uncontrolled seizure (AOR: 108.37, 95%CI: 38.7-303.6) exhibited significant associations with drug therapy problems. Drug therapy problems were prevalent among patients with epilepsy. The use of combination therapy and the presence of uncontrolled seizures were identified as significant indicators of drug therapy problems. Therefore, more emphasis should be given to patients with multiple medications and uncontrolled seizures.
  • Publisher: United States: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0299968
    PMID: 38451979
  • Source: PubMed
    PLoS (Open access)
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    ProQuest Central
    DOAJ Directory of Open Access Journals
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