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Comparison of amlodipine with cilnidipine on antihypertensive efficacy and incidence of pedal edema in mild to moderate hypertensive individuals: A prospective study

Journal of advanced pharmaceutical technology and research, 2015-04, Vol.6 (2), p.81-85 [Peer Reviewed Journal]

COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd. ;2015. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright: © Journal of Advanced Pharmaceutical Technology & Research 2015 ;ISSN: 2231-4040 ;EISSN: 0976-2094 ;DOI: 10.4103/2231-4040.154543 ;PMID: 25878978

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  • Title:
    Comparison of amlodipine with cilnidipine on antihypertensive efficacy and incidence of pedal edema in mild to moderate hypertensive individuals: A prospective study
  • Author: Adake, Prabhakar ; Somashekar, H S ; Mohammed Rafeeq, P K ; Umar, Dilshad ; Basheer, Bahija ; Baroudi, Kusai
  • Subjects: Age ; Analysis ; Angina pectoris ; Antihypertensive agents ; Antihypertensives ; Blood pressure ; Calcium ; calcium channel blockers ; Calcium channels (L-type) ; Calcium channels (N-type) ; Cardiovascular disease ; Cilnidipine ; Diabetes ; Diuretics ; Drugs ; Edema ; Family medical history ; Health risk assessment ; Hypertension ; N-type and T-type calcium channels ; Original ; Patients
  • Is Part Of: Journal of advanced pharmaceutical technology and research, 2015-04, Vol.6 (2), p.81-85
  • Description: To compare amlodipine with cilnidipine on antihypertensive efficacy and incidence of pedal edema in hypertensive individuals. This was a three months prospective, observational study done at the tertiary care center of Karnataka, India. A total number of 60 (n = 60) newly diagnosed hypertensives (≥140/90) of either gender, attending outpatient department of medicine, were included in the study. Out of 60 patients, 30 patients who have been prescribed tablet amlodipine 5-10 mg/day and the other 30 who have been prescribed tablet cilnidipine 10-20 mg/day orally by the consulting physician, depending upon the severity of hypertension were followed every fortnight, screened for the presence of pedal edema and blood pressure control over a period of 3 months. Antihypertensive efficacy between two groups was compared by unpaired t-test and incidence of pedal edema was compared by Fisher's exact test. Of 30 patients in the amlodipine group, 19 patients presented with pedal edema (63.3%) and 2 patients (6.66%) in cilnidipine group presented with pedal edema during the study period. There was a significant difference in the incidence of pedal edema between amlodipine and cilnidipine group (P < 0.05), but no significant difference was found in the antihypertensive efficacy of amlodipine and cilnidipine (P > 0.05). Both amlodipine and cilnidipine have shown equal efficacy in reducing blood pressure in hypertensive individuals. But cilnidipine being N-type and L-type calcium channel blocker, associated with lower incidence of pedal edema compared to only L-type channel blocked by amlodipine.
  • Publisher: India: Medknow Publications and Media Pvt. Ltd
  • Language: English
  • Identifier: ISSN: 2231-4040
    EISSN: 0976-2094
    DOI: 10.4103/2231-4040.154543
    PMID: 25878978
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    Directory of Open Access Journals
    Medknow Open Access Medical Journals
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
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