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A connectome and analysis of the adult Drosophila central brain

eLife, 2020-09, Vol.9 [Peer Reviewed Journal]

2020, Scheffer et al. ;2020, Scheffer et al 2020 Scheffer et al ;ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/elife.57443 ;PMID: 32880371

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Title:
A connectome and analysis of the adult Drosophila central brain
Author: Xu, C Shan ; Januszewski, Michal ; Lu, Zhiyuan ; Takemura, Shin-Ya ; Hayworth, Kenneth J ; Huang, Gary B ; Shinomiya, Kazunori ; Berg, Stuart ; Clements, Jody ; Hubbard, Philip M ; Katz, William T ; Umayam, Lowell ; Zhao, Ting ; Ackerman, David ; Blakely, Tim ; Bogovic, John ; Dolafi, Tom ; Kainmueller, Dagmar ; Kawase, Takashi ; Khairy, Khaled A ; Leavitt, Laramie ; Li, Peter H ; Lindsey, Larry ; Neubarth, Nicole ; Olbris, Donald J ; Otsuna, Hideo ; Trautman, Eric T ; Ito, Masayoshi ; Bates, Alexander S ; Goldammer, Jens ; Svirskas, Robert ; Schlegel, Philipp ; Neace, Erika ; Knecht, Christopher J ; Alvarado, Chelsea X ; Bailey, Dennis A ; Ballinger, Samantha ; Borycz, Jolanta A ; Canino, Brandon S ; Cheatham, Natasha ; Cook, Michael ; Dreher, Marisa ; Duclos, Octave ; Fairbanks, Kelli ; Finley, Samantha ; Forknall, Nora ; Francis, Audrey ; Hopkins, Gary Patrick ; Joyce, Emily M ; Kim, SungJin ; Kirk, Nicole A ; Kovalyak, Julie ; Lauchie, Shirley A ; Lohff, Alanna ; Maldonado, Charli ; Manley, Emily A ; McLin, Sari ; Mooney, Caroline ; Ndama, Miatta ; Ogundeyi, Omotara ; Okeoma, Nneoma ; Ordish, Christopher ; Padilla, Nicholas ; Patrick, Christopher M ; Paterson, Tyler ; Phillips, Elliott E ; Rampally, Neha ; Ribeiro, Caitlin ; Robertson, Madelaine K ; Rymer, Jon Thomson ; Ryan, Sean M ; Sammons, Megan ; Scott, Anne K ; Scott, Ashley L ; Shinomiya, Aya ; Smith, Claire ; Smith, Kelsey ; Smith, Natalie L ; Sobeski, Margaret A ; Swift, Jackie ; Takemura, Satoko ; Talebi, Iris ; Tarnogorska, Dorota ; Tokhi, Temour ; Walsh, John J ; Horne, Jane Anne ; Li, Feng ; Parekh, Ruchi ; Rivlin, Patricia K ; Jayaraman, Vivek ; Costa, Marta ; Jefferis, Gregory Sxe ; Ito, Kei ; Saalfeld, Stephan ; George, Reed ; Meinertzhagen, Ian A ; Rubin, Gerald M ; Hess, Harald F ; Jain, Viren ; Plaza, Stephen M
Subjects: Animals ; Brain - physiology ; brain regions ; cell types ; Computational and Systems Biology ; connectome ; Connectome - methods ; connectome reconstuction methods ; Drosophila melanogaster - physiology ; Female ; graph properties ; Male ; Neurons - physiology ; Neuroscience ; synapse detecton ; Synapses - physiology
Is Part Of: eLife, 2020-09, Vol.9
Description: The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly . Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly's brain.
Publisher: England: eLife Sciences Publications, Ltd
Language: English
Identifier: ISSN: 2050-084X
EISSN: 2050-084X
DOI: 10.7554/elife.57443
PMID: 32880371
Source: MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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A connectome and analysis of the adult Drosophila central brain

2020, Scheffer et al. ;2020, Scheffer et al 2020 Scheffer et al ;ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/elife.57443 ;PMID: 32880371

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