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Chlorpromazine-induced status epilepticus: a case report
Srpski arhiv za celokupno lekarstvo, 2013-09, Vol.141 (9-10), p.667-670
ISSN: 0370-8179 ;EISSN: 2406-0895 ;DOI: 10.2298/SARH1310667M ;PMID: 24364231
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Title:
Chlorpromazine-induced status epilepticus: a case report
Author:
Momcilović-Kostadinović, Dragana
;
Simonović, Perisa
;
Kolar, Dusan
;
Jović, Nebojsa
Subjects:
Adolescent
;
adolescents
;
Antipsychotic Agents - adverse effects
;
Anxiety Disorders - drug therapy
;
chlorpromazine
;
Chlorpromazine - adverse effects
;
Female
;
Humans
;
myoclonic status epilepticus
;
Risk Factors
;
Status Epilepticus - chemically induced
Is Part Of:
Srpski arhiv za celokupno lekarstvo, 2013-09, Vol.141 (9-10), p.667-670
Description:
It is largely known that some antipsychotic agents could have proconvulsive and proepileptogenic effects in some patients and could induce EEG abnormalities as well. However, the association of status epilepticus with certain antipsychotic drugs has been very rarely reported. A case of an 18-year-old adolescent girl, with chlorpromazine therapy started for anxiety-phobic disorder was reported. Her personal history disclosed delayed psychomotor development. Shortly after the introduction of the neuroleptic chlorpromazine therapy in minimal daily dose (37.5 mg), she developed myoclonic status epilepticus, confirmed by the EEG records. Frequent, symmetrical bilateral myoclonic jerks and altered behavior were associated with bilateral epileptiform discharges of polyspikes and spike-wave complexes. This epileptic event lasted 3.5 hours and it was stopped by the parenteral administration ofvalproate and lorazepam; she was EEG monitored until stable remission. Status epilepticus as initial epileptic event induced by neuroleptic agent was not previously reported in our national literature. Introduction of chlorpromazine to a patient without history of seizures is associated with the evolution of an epileptic activity, including the occurrence of status epilepticus. Clinical evaluation of the risk factors possibly related to chlorpromazine-induced seizure is recommended in individual patients before administering this drug.
Publisher:
Serbia: Serbian Medical Society
Language:
Serbian;English
Identifier:
ISSN: 0370-8179
EISSN: 2406-0895
DOI: 10.2298/SARH1310667M
PMID: 24364231
Source:
MEDLINE
DOAJ Directory of Open Access Journals
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