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Viral RNA Load in Symptomatic and Asymptomatic COVID-19 Omicron Variant-Positive Patients

Canadian respiratory journal, 2022, Vol.2022, p.1-6 [Peer Reviewed Journal]

Copyright © 2022 Qian Wu et al. ;Copyright © 2022 Qian Wu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 ;Copyright © 2022 Qian Wu et al. 2022 ;ISSN: 1198-2241 ;EISSN: 1916-7245 ;DOI: 10.1155/2022/5460400 ;PMID: 36072643

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  • Title:
    Viral RNA Load in Symptomatic and Asymptomatic COVID-19 Omicron Variant-Positive Patients
  • Author: Wu, Qian ; Shi, Lixia ; Li, Haomin ; Huang, Shuping ; Li, Hongwei ; Li, Li ; Han, Jin ; Wu, Qi ; Pei, Zhengcun
  • Corlateanu, Alexandru ; Alexandru Corlateanu
  • Subjects: Acids ; Age groups ; Asymptomatic ; Blood diseases ; Cardiovascular disease ; Comorbidity ; Coronary vessels ; Coronaviruses ; COVID-19 vaccines ; Diabetes ; Genomes ; Hypertension ; Mutation ; Patients ; Severe acute respiratory syndrome coronavirus 2 ; Variables ; Vein & artery diseases
  • Is Part Of: Canadian respiratory journal, 2022, Vol.2022, p.1-6
  • Description: Objectives. Viral load is important when evaluating viral transmission potential, involving the use of a polymerase chain reaction (PCR) cycle threshold (Ct) value. We aimed to analyze the PCR Ct values of respiratory tract samples taken from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant strains to evaluate these strains’ viral dynamics. Methods. This study comprised 361 patients. The Ct values of SARS-CoV-2-related respiratory samples were compared between symptomatic and asymptomatic patients. Results. The median (25th percentile and 75th percentile) nasopharynx and oropharynx SARS-CoV-2 Ct values were 30.5 (24.5–35.0) and 34.5 (30.0–37.0) in the symptomatic group, respectively, and 27.8 (23.4–34.5) and 33.5 (26.0–35.0) in the asymptomatic group, respectively, without significance. In the symptomatic group, subgroup analyses according to age showed the mean nasal Ct value for patients aged >18 years was 29.0 (23.5–34.5), which was significantly lower than that of patients aged 0–4 years and 5–13 years (36.0 (30.5–38.0) and 34.5 (31.0–39.0), respectively). The nasal Ct value for asymptomatic patients aged >18 years was 25.5 (20.9–28.4), which was significantly lower than of patients aged 5–13 years (34.5 (25.6–36.4)). Conclusion. Our findings suggest that the viral loads of asymptomatic and symptomatic patients did not differ significantly. However, adults infected with SARS-CoV-2 had higher nasal viral loads that those of young children.
  • Publisher: Oakville: Hindawi
  • Language: English;French
  • Identifier: ISSN: 1198-2241
    EISSN: 1916-7245
    DOI: 10.1155/2022/5460400
    PMID: 36072643
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
    Coronavirus Research Database
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