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Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

Scientific reports, 2018-04, Vol.8 (1), p.6451-9, Article 6451 [Peer Reviewed Journal]

Copyright Nature Publishing Group Apr 2018 ;The Author(s) 2018 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-018-24735-y ;PMID: 29691431

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Title:
Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank
Author: Tikkanen, Emmi ; Gustafsson, Stefan ; Amar, David ; Shcherbina, Anna ; Waggott, Daryl ; Ashley, Euan A ; Ingelsson, Erik
Subjects: Atrial Fibrillation - genetics ; Biological Specimen Banks ; Cardiovascular disease ; Cognition ; Cognitive ability ; Coronary artery disease ; Coronary Disease - genetics ; Developmental disabilities ; Female ; Fibrillation ; Gene expression ; Genetic diversity ; Genetic Variation - genetics ; Genome-wide association studies ; Genome-Wide Association Study - methods ; Genomes ; Hand Strength ; Heart diseases ; Humans ; Male ; Muscle strength ; Muscle Strength - genetics ; Neurodevelopmental disorders ; Polymorphism, Single Nucleotide - genetics ; Quantitative Trait Loci - genetics ; United Kingdom
Is Part Of: Scientific reports, 2018-04, Vol.8 (1), p.6451-9, Article 6451
Description: We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength (P <5 × 10 ). Of these, 64 were associated (P < 0.01 and consistent direction) also in the replication dataset (N = 111,610). eQTL analyses highlighted several genes known to play a role in neuro-developmental disorders or brain function, and the results from meta-analysis showed a significant enrichment of gene expression of brain-related transcripts. Further, we observed inverse genetic correlations of grip strength with cardiometabolic traits, and positive correlation with parents' age of death and education. We also showed that grip strength had shared biological pathways with indicators of frailty, including cognitive performance scores. By use of Mendelian randomization, we provide evidence that higher grip strength is protective of both coronary heart disease (OR = 0.69, 95% CI 0.60-0.79, P < 0.0001) and atrial fibrillation (OR = 0.75, 95% CI 0.62-0.90, P = 0.003). In conclusion, our results show shared genetic aetiology between grip strength, and cardiometabolic and cognitive health; and suggest that maintaining muscular strength could prevent future cardiovascular events.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/s41598-018-24735-y
PMID: 29691431
Source: MEDLINE
PubMed Central
SWEPUB Freely available online
ProQuest Central
DOAJ Directory of Open Access Journals

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Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank

Copyright Nature Publishing Group Apr 2018 ;The Author(s) 2018 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-018-24735-y ;PMID: 29691431

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