Language:

Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey, May-June 2020

Indian journal of medical research (New Delhi, India : 1994), 2020-01, Vol.152 (1), p.48-60 [Peer Reviewed Journal]

COPYRIGHT 2020 Medknow Publications and Media Pvt. Ltd. ;2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright: © 2020 Indian Journal of Medical Research 2020 ;ISSN: 0971-5916 ;EISSN: 0975-9174 ;DOI: 10.4103/ijmr.IJMR_3290_20 ;PMID: 32952144

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey, May-June 2020
Author: Murhekar, Manoj ; Bhatnagar, Tarun ; Selvaraju, Sriram ; Rade, Kiran ; Saravanakumar, V ; Vivian Thangaraj, Jeromie ; Kumar, Muthusamy ; Shah, Naman ; Sabarinathan, R ; Turuk, Alka ; Anand, Parveen ; Asthana, Smita ; Balachandar, Rakesh ; Bangar, Sampada ; Bansal, Avi ; Bhat, Jyothi ; Chakraborty, Debjit ; Rangaraju, Chethana ; Chopra, Vishal ; Das, Dasarathi ; Deb, Alok ; Devi, Kangjam ; Dwivedi, Gaurav ; Salim Khan, S ; Haq, Inaamul ; Kumar, M ; Laxmaiah, Avula ; Mahapatra, Amarendra ; Mitra, Anindya ; Nirmala, A ; Pagdhune, Avinash ; Qurieshi, Mariya ; Ramarao, Tekumalla ; Sahay, Seema ; Sharma, Y ; Shrinivasa, Marinaik ; Shukla, Vijay ; Singh, Prashant ; Viramgami, Ankit ; Wilson, Vimith ; Yadav, Rajiv ; Girish Kumar, C ; Luke, Hanna ; Ranganathan, Uma ; Babu, Subash ; Sekar, Krithikaa ; Yadav, Pragya ; Sapkal, Gajanan ; Das, Aparup ; Das, Pradeep ; Dutta, Shanta ; Hemalatha, Rajkumar ; Kumar, Ashwani ; Narain, Kanwar ; Narasimhaiah, Somashekar ; Panda, Samiran ; Pati, Sanghamitra ; Patil, Shripad ; Sarkar, Kamalesh ; Singh, Shalini ; Kant, Rajni ; Tripathy, Srikanth ; Toteja, G ; Babu, Giridhara ; Kant, Shashi ; Muliyil, J ; Pandey, Ravindra ; Sarkar, Swarup ; Singh, Sujeet ; Zodpey, Sanjay ; Gangakhedkar, Raman ; S. Reddy, D ; Bhargava, Balram
Subjects: Adolescent ; Adult ; Adults ; Aged ; Antibodies, Viral - blood ; antibody - covid-19 - elisa - igg - india - sars-cov-2 - seroepidemiology - seroprevalence - serosurveillance ; Betacoronavirus - genetics ; Betacoronavirus - pathogenicity ; Coronavirus Infections - blood ; Coronavirus Infections - epidemiology ; Coronavirus Infections - virology ; COVID-19 ; Enzyme-Linked Immunosorbent Assay ; Female ; Health aspects ; Humans ; Immunoglobulin G - blood ; India - epidemiology ; Infections ; Male ; Medical research ; Middle Aged ; Original ; Pandemics ; Pneumonia, Viral - blood ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - virology ; Population ; SARS-CoV-2 ; Seroepidemiologic Studies ; Severe acute respiratory syndrome coronavirus 2 ; Young Adult
Is Part Of: Indian journal of medical research (New Delhi, India : 1994), 2020-01, Vol.152 (1), p.48-60
Description: Background & objectives: Population-based seroepidemiological studies measure the extent of SARS-CoV-2 infection in a country. We report the findings of the first round of a national serosurvey, conducted to estimate the seroprevalence of SARS-CoV-2 infection among adult population of India. Methods: From May 11 to June 4, 2020, a randomly sampled, community-based survey was conducted in 700 villages/wards, selected from the 70 districts of the 21 States of India, categorized into four strata based on the incidence of reported COVID-19 cases. Four hundred adults per district were enrolled from 10 clusters with one adult per household. Serum samples were tested for IgG antibodies using COVID Kavach ELISA kit. All positive serum samples were re-tested using Euroimmun SARS-CoV-2 ELISA. Adjusting for survey design and serial test performance, weighted seroprevalence, number of infections, infection to case ratio (ICR) and infection fatality ratio (IFR) were calculated. Logistic regression was used to determine the factors associated with IgG positivity. Results: Total of 30,283 households were visited and 28,000 individuals were enrolled. Population-weighted seroprevalence after adjusting for test performance was 0.73 per cent [95% confidence interval (CI): 0.34-1.13]. Males, living in urban slums and occupation with high risk of exposure to potentially infected persons were associated with seropositivity. A cumulative 6,468,388 adult infections (95% CI: 3,829,029-11,199,423) were estimated in India by the early May. The overall ICR was between 81.6 (95% CI: 48.3-141.4) and 130.1 (95% CI: 77.0-225.2) with May 11 and May 3, 2020 as plausible reference points for reported cases. The IFR in the surveyed districts from high stratum, where death reporting was more robust, was 11.72 (95% CI: 7.21-19.19) to 15.04 (9.26-24.62) per 10,000 adults, using May 24 and June 1, 2020 as plausible reference points for reported deaths. Interpretation & conclusions: Seroprevalence of SARS-CoV-2 was low among the adult population in India around the beginning of May 2020. Further national and local serosurveys are recommended to better inform the public health strategy for containment and mitigation of the epidemic in various parts of the country.
Publisher: India: Wolters Kluwer India Pvt. Ltd
Language: English
Identifier: ISSN: 0971-5916
EISSN: 0975-9174
DOI: 10.4103/ijmr.IJMR_3290_20
PMID: 32952144
Source: Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey, May-June 2020

Searching Remote Databases, Please Wait