Language:

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

Journal of diabetes research, 2016-01, Vol.2016, p.2156273-17 [Peer Reviewed Journal]

Copyright © 2016 Pedro Romero-Aroca et al. ;Copyright © 2016 Pedro Romero-Aroca et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright © 2016 Pedro Romero-Aroca et al. 2016 ;ISSN: 2314-6745 ;EISSN: 2314-6753 ;DOI: 10.1155/2016/2156273 ;PMID: 27761468

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory
Author: Romero-Aroca, Pedro ; Baget-Bernaldiz, Marc ; Pareja-Rios, Alicia ; Lopez-Galvez, Maribel ; Navarro-Gil, Raul ; Verges, Raquel
Petrovski, Goran ; Goran Petrovski
Subjects: Angiogenesis ; Cysts ; Diabetes ; Diabetes Mellitus - immunology ; Diabetes Mellitus - metabolism ; Diabetic retinopathy ; Diabetic Retinopathy - etiology ; Diabetic Retinopathy - immunology ; Diabetic Retinopathy - metabolism ; Edema ; Etiology ; Humans ; Inflammation ; Inflammation - etiology ; Inflammation - immunology ; Inflammation - metabolism ; Macular Edema - etiology ; Macular Edema - immunology ; Macular Edema - metabolism ; Metabolism ; Neovascularization, Pathologic - etiology ; Neovascularization, Pathologic - immunology ; Neovascularization, Pathologic - metabolism ; Pathophysiology ; Photoreceptors ; Retina ; Retina - immunology ; Retina - metabolism ; Review ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - immunology ; Vascular Endothelial Growth Factor A - metabolism
Is Part Of: Journal of diabetes research, 2016-01, Vol.2016, p.2156273-17
Description: Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF overexpression is a cause or a consequence of inflammation. This paper provides a review of the data currently available, focusing on VEGF, angiogenesis, and inflammation. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. Knowledge of DME etiology seems to be important in treatments with anti-VEGF or anti-inflammatory drugs. Current diagnostic techniques do not permit us to differentiate between both etiologies. In the future, diagnosing the physiopathology of each patient with DME will help us to select the most effective drug.
Publisher: England: Hindawi Publishing Corporation
Language: English
Identifier: ISSN: 2314-6745
EISSN: 2314-6753
DOI: 10.1155/2016/2156273
PMID: 27761468
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

Searching Remote Databases, Please Wait