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Circulating levels of adiponectin and extent of coronary artery disease in patients undergoing elective coronary angiography

Brazilian journal of medical and biological research, 2018-01, Vol.51 (2), p.e6738-e6738 [Peer Reviewed Journal]

COPYRIGHT 2018 Associacao Brasileira de Divulgacao Cientifica (ABDC) ;COPYRIGHT 2018 Associacao Brasileira de Divulgacao Cientifica (ABDC) ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0100-879X ;ISSN: 1414-431X ;EISSN: 1414-431X ;DOI: 10.1590/1414-431X20176738 ;PMID: 29211251

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  • Title:
    Circulating levels of adiponectin and extent of coronary artery disease in patients undergoing elective coronary angiography
  • Author: Souza, R A ; Alves, C M R ; de Oliveira, C S V ; Reis, A F ; Carvalho, A C
  • Subjects: Adipokines ; Adiponectin ; Adipose tissue ; Adipose tissues ; Angiography ; Atherosclerosis ; BIOLOGY ; Cardiac patients ; Coronary artery disease ; Coronary heart disease ; Health aspects ; MEDICINE, RESEARCH & EXPERIMENTAL ; Physiological aspects ; Risk factors
  • Is Part Of: Brazilian journal of medical and biological research, 2018-01, Vol.51 (2), p.e6738-e6738
  • Description: Adiponectin (APN), an adipose tissue-released adipokine with demonstrated anti-inflammatory and anti-atherogenic properties, is encoded by a gene whose polymorphisms are associated with presence of coronary artery disease (CAD). Serum APN levels are inversely related with presence and complexity of CAD. Within this context, we sought to compare levels of total APN and its high molecular weight form (HMW APN) according to clinical presentation and extent of CAD in patients undergoing elective cardiac catheterization. From March 2008 to June 2010, clinical data and blood samples for APN and HMW APN measurements were collected from 415 subjects undergoing cardiac catheterization at two tertiary centers. CAD extent was estimated by the number of coronary arteries with significant stenosis (≥70% obstruction in a major coronary artery) and by Duke Jeopardy Score (DJS). Serum APN levels were similar between groups with stable or unstable CAD (APN 9.20±5.88 vs 9.47±6.23 μg/mL, P=0.738, and HMW APN 5.31±3.72 vs 5.91±4.16 μg/mL, P=0.255), even after stratification by the number of arteries involved (single-vessel vs multivessel disease: APN 9.39±5.76 vs 9.26±6.27 μg/mL, P=0.871; HMW APN 5.29±3.79 vs 5.83±4.04 μg/mL, P=0.306) and DJS score (APN, P=0.718; HMW APN, P=0.276). We conclude that APN and HMW APN serum levels are similar across clinical presentations and different extents of CAD, despite being significantly lower in the presence of obstructive CAD.
  • Publisher: Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)
  • Language: English;Portuguese
  • Identifier: ISSN: 0100-879X
    ISSN: 1414-431X
    EISSN: 1414-431X
    DOI: 10.1590/1414-431X20176738
    PMID: 29211251
  • Source: Freely Accessible Journals
    SciELO
    PubMed Central
    DOAJ Directory of Open Access Journals
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