skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Impact of Diabetes Mellitus on Antithrombotic Management Patterns and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndrome: Insights From the EPICOR Asia Study

Journal of the American Heart Association, 2020-11, Vol.9 (22), p.e013476 [Peer Reviewed Journal]

2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. ;ISSN: 2047-9980 ;EISSN: 2047-9980 ;DOI: 10.1161/JAHA.119.013476 ;PMID: 33164633

Full text available

Citations Cited by
  • Title:
    Impact of Diabetes Mellitus on Antithrombotic Management Patterns and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndrome: Insights From the EPICOR Asia Study
  • Author: Guan, Shaoyi ; Xu, Xiaoming ; Li, Yi ; Li, Jing ; Guan, Mingzi ; Wang, Xiaozeng ; Jing, Quanmin ; Huo, Yong ; Han, Yaling
  • Subjects: acute coronary syndrome ; Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - drug therapy ; Aged ; antiplatelet agents ; Asia ; Cohort Studies ; Diabetes Complications - complications ; diabetes mellitus ; Female ; Fibrinolytic Agents - therapeutic use ; Humans ; Male ; Middle Aged ; Original Research ; Outcome Assessment, Health Care ; Platelet Aggregation Inhibitors - therapeutic use ; Propensity Score
  • Is Part Of: Journal of the American Heart Association, 2020-11, Vol.9 (22), p.e013476
  • Description: Background Long-term use of antiplatelet agents after acute coronary syndrome in diabetic patients is not well known. Here, we describe antiplatelet use and outcomes in such patients enrolled in the EPICOR Asia (Long-Term Follow-up of Antithrombotic Management Patterns in Acute Coronary Syndrome Patients in Asia) registry. Methods and Results EPICOR Asia is a prospective, observational study of 12 922 patients with acute coronary syndrome surviving to discharge, from 8 countries/regions in Asia. The present analysis included 3162 patients with diabetes mellitus (DM) and 9602 patients without DM. The impact of DM on use of antiplatelet agents and events (composite of death, myocardial infarction, and stroke, with or without any revascularization; individual components, and bleeding) was evaluated. Significant baseline differences were seen between patients with DM and patients without DM for age, sex, body mass index, cardiovascular history, angiographic findings, and use of percutaneous coronary intervention. At discharge, ≈90% of patients in each group received dual antiplatelet therapy. At 2-year follow-up, more patients with DM tended to still receive dual antiplatelet therapy (60% versus 56%). DM was associated with increased risk from ischemic but not major bleeding events. Independent predictors of the composite end point of death, myocardial infarction, and stroke in patients with DM were age ≥65 years and use of diuretics at discharge. Conclusions Antiplatelet agent use is broadly comparable in patients with DM and patients without DM, although patients with DM are more likely to be on dual antiplatelet therapy at 2 years. Patients with DM are at increased risk of ischemic events, suggesting an unmet need for improved antithrombotic treatment. Registration URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT01361386.
  • Publisher: England: John Wiley and Sons Inc
  • Language: English
  • Identifier: ISSN: 2047-9980
    EISSN: 2047-9980
    DOI: 10.1161/JAHA.119.013476
    PMID: 33164633
  • Source: Open Access: Wiley Blackwell Open Access Journals
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait