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Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

Nature communications, 2023-02, Vol.14 (1), p.744-744, Article 744 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-023-36454-8 ;PMID: 36765071

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Title:
Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals
Author: Cao, Rangjuan ; Chen, Peng ; Wang, Hongsheng ; Jing, Hongyang ; Zhang, Hongsheng ; Xing, Guanglin ; Luo, Bin ; Pan, Jinxiu ; Yu, Zheng ; Xiong, Wen-Cheng ; Mei, Lin
Subjects: Amyloid beta-Protein Precursor - metabolism ; Animals ; Egr-3 protein ; LDL-Receptor Related Proteins - metabolism ; Locomotion ; Maintenance ; Mice ; Muscle contraction ; Muscle spindles ; Muscle Spindles - metabolism ; Muscles ; Muscular function ; Mutation ; Nerve endings ; Neuromuscular Junction - metabolism ; Neuromuscular junctions ; Proprioception ; Sensory neurons ; Sensory Receptor Cells ; Synapses ; Terminals
Is Part Of: Nature communications, 2023-02, Vol.14 (1), p.744-744, Article 744
Description: Proprioception is sensed by muscle spindles for precise locomotion and body posture. Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well studied, mechanisms of spindle formation are not well understood. Here we show that sensory nerve terminals are disrupted by the mutation of Lrp4, a gene required for NMJ formation; inducible knockout of Lrp4 in adult mice impairs sensory synapses and movement coordination, suggesting that LRP4 is required for spindle formation and maintenance. LRP4 is critical to the expression of Egr3 during development; in adult mice, it interacts in trans with APP and APLP2 on sensory terminals. Finally, spindle sensory endings and function are impaired in aged mice, deficits that could be diminished by LRP4 expression. These observations uncovered LRP4 as an unexpected regulator of muscle spindle formation and maintenance in adult and aged animals and shed light on potential pathological mechanisms of abnormal muscle proprioception.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-023-36454-8
PMID: 36765071
Source: DOAJ Directory of Open Access Journals
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PubMed Central
ProQuest Central

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Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

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