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Action and resistance mechanisms of antibiotics: A guide for clinicians

Journal of anaesthesiology, clinical pharmacology, 2017-07, Vol.33 (3), p.300-305 [Peer Reviewed Journal]

COPYRIGHT 2017 Research Society of Anaesthesiology Clinical Pharmacology ;COPYRIGHT 2017 Medknow Publications and Media Pvt. Ltd. ;Copyright: © 2017 Journal of Anaesthesiology Clinical Pharmacology 2017 ;ISSN: 0970-9185 ;EISSN: 2231-2730 ;DOI: 10.4103/joacp.joacp_349_15 ;PMID: 29109626

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  • Title:
    Action and resistance mechanisms of antibiotics: A guide for clinicians
  • Author: Kapoor, Garima ; Saigal, Saurabh ; Elongavan, Ashok
  • Subjects: Antibiotics ; antimicrobial resistance ; Bacteria ; bacterial cell wall ; Care and treatment ; Developing countries ; Drug resistance in microorganisms ; mechanism of action ; Microbial drug resistance ; Permeability ; Review
  • Is Part Of: Journal of anaesthesiology, clinical pharmacology, 2017-07, Vol.33 (3), p.300-305
  • Description: Infections account for a major cause of death throughout the developing world. This is mainly due to the emergence of newer infectious agents and more specifically due to the appearance of antimicrobial resistance. With time, the bacteria have become smarter and along with it, massive imprudent usage of antibiotics in clinical practice has resulted in resistance of bacteria to antimicrobial agents. The antimicrobial resistance is recognized as a major problem in the treatment of microbial infections. The biochemical resistance mechanisms used by bacteria include the following: antibiotic inactivation, target modification, altered permeability, and "bypass" of metabolic pathway. Determination of bacterial resistance to antibiotics of all classes (phenotypes) and mutations that are responsible for bacterial resistance to antibiotics (genetic analysis) are helpful. Better understanding of the mechanisms of antibiotic resistance will help clinicians regarding usage of antibiotics in different situations. This review discusses the mechanism of action and resistance development in commonly used antimicrobials.
  • Publisher: India: Medknow Publications and Media Pvt. Ltd
  • Language: English
  • Identifier: ISSN: 0970-9185
    EISSN: 2231-2730
    DOI: 10.4103/joacp.joacp_349_15
    PMID: 29109626
  • Source: GFMER Free Medical Journals
    PubMed Central
    Medknow Open Access Medical Journals
    DOAJ Directory of Open Access Journals
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