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Mechanisms for the Risk of Acute Coronary Syndrome and Arrhythmia Associated With Phytogenic and Synthetic Cannabinoid Use

Journal of Cardiovascular Pharmacology and Therapeutics, 2020-11, Vol.25 (6), p.508-522

The Author(s) 2020 ;ISSN: 1074-2484 ;EISSN: 1940-4034 ;DOI: 10.1177/1074248420935743

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  • Title:
    Mechanisms for the Risk of Acute Coronary Syndrome and Arrhythmia Associated With Phytogenic and Synthetic Cannabinoid Use
  • Author: Richards, John R.
  • Is Part Of: Journal of Cardiovascular Pharmacology and Therapeutics, 2020-11, Vol.25 (6), p.508-522
  • Description: Phytogenic cannabinoids from Cannabis sativa and synthetic cannabinoids are commonly used substances for their recreational and medicinal properties. There are increasing reports of cardiotoxicity in close temporal association with cannabinoid use in patients with structurally normal hearts and absence of coronary arterial disease. Associated adverse events include myocardial ischemia, conduction abnormalities, arrhythmias, and sudden death. This review details the effects of phytogenic and synthetic cannabinoids on diverse receptors based on evidence from in vitro, human, and animal studies to establish a molecular basis for these deleterious clinical effects. The synergism between endocannabinoid dysregulation, cannabinoid receptor, and noncannabinoid receptor binding, and impact on cellular ion flux and coronary microvascular circulation is delineated. Pharmacogenetic factors placing certain patients at higher risk for cardiotoxicity are also correlated with the diverse effects of cannabinoids.
  • Publisher: Los Angeles, CA: SAGE Publications
  • Language: English
  • Identifier: ISSN: 1074-2484
    EISSN: 1940-4034
    DOI: 10.1177/1074248420935743
  • Source: Journals@Ovid Open Access Journal Collection Rolling
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