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Preprint Highlight: Polarized Disheveled dissolution and condensation drives embryonic axis specification in oocytes

Molecular biology of the cell, 2022-05, Vol.33 (5), p.mbcP22031002 [Peer Reviewed Journal]

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Title:
Preprint Highlight: Polarized Disheveled dissolution and condensation drives embryonic axis specification in oocytes
Author: Dudin, Omaya
Subjects: Body Patterning ; Oocytes ; Solubility
Is Part Of: Molecular biology of the cell, 2022-05, Vol.33 (5), p.mbcP22031002
Description: Body axes establishment during animal embryogenesis often relies on the intrinsic asymmetry generated early on in the oocyte by the Wnt/β-catenin pathway. However, it's still unclear how the initial asymmetry arises. Here imaging experiments show that in starfish embryos, Disheveled (Dvl), an essential cytoplasmic transducer of Wnt signaling, becomes polarized at the vegetal pole via a dissolution-condensation mechanism coupled to meiotic progression. The authors further show that Dvl reformation is dependent on a maternally expressed Wnt signaling receptor Frizzled (Fzd1). This study identifies a novel link between the cell cycle and the body plan establishment and thus is relevant to a broad audience of developmental and evolutionary cell biologists.
Publisher: United States
Language: English
Identifier: ISSN: 1059-1524
EISSN: 1939-4586
DOI: 10.1091/mbc.P22-03-1002
PMID: 35482511
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

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