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Facile fabrication of a silicon nanowire sensor by two size reduction steps for detection of alpha-fetoprotein biomarker of liver cancer

Advances in natural sciences. Nanoscience and nanotechnology, 2015-12, Vol.6 (4), p.45001-6 [Peer Reviewed Journal]

2015 Vietnam Academy of Science & Technology ;ISSN: 2043-6262 ;ISSN: 2043-6254 ;EISSN: 2043-6262 ;DOI: 10.1088/2043-6262/6/4/045001 ;CODEN: ANSNCK

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  • Title:
    Facile fabrication of a silicon nanowire sensor by two size reduction steps for detection of alpha-fetoprotein biomarker of liver cancer
  • Author: Pham, Van Binh ; Pham, Xuan ThanhTung ; Phan, Thanh Nhat Khoa ; Le, Thi Thanh Tuyen ; Dang, Mau Chien
  • Subjects: AFP detection ; Biomarkers ; biosensor ; Biosensors ; Cancer ; Diagnosis ; GPTS ; Liver ; liver cancer ; Nanowires ; Sensors ; Silicon ; silicon nanowire ; surface modification
  • Is Part Of: Advances in natural sciences. Nanoscience and nanotechnology, 2015-12, Vol.6 (4), p.45001-6
  • Description: We present a facile technique that only uses conventional micro-techniques and two size-reduction steps to fabricate wafer-scale silicon nanowire (SiNW) with widths of 200 nm. Initially, conventional lithography was used to pattern SiNW with 2 m width. Then the nanowire width was decreased to 200 nm by two size-reduction steps with isotropic wet etching. The fabricated SiNW was further investigated when used with nanowire field-effect sensors. The electrical characteristics of the fabricated SiNW devices were characterized and pH sensitivity was investigated. Then a simple and effective surface modification process was carried out to modify SiNW for subsequent binding of a desired receptor. The complete SiNW-based biosensor was then used to detect alpha-fetoprotein (AFP), one of the medically approved biomarkers for liver cancer diagnosis. Electrical measurements showed that the developed SiNW biosensor could detect AFP with concentrations of about 100 ng mL−1. This concentration is lower than the necessary AFP concentration for liver cancer diagnosis.
  • Publisher: IOP Publishing
  • Language: English
  • Identifier: ISSN: 2043-6262
    ISSN: 2043-6254
    EISSN: 2043-6262
    DOI: 10.1088/2043-6262/6/4/045001
    CODEN: ANSNCK
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    IOPscience (Open Access)
    IOP Publishing Free Content(OpenAccess)
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