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Detecting the golgi protein 73 of liver cancer with micro cantilever

Advances in natural sciences. Nanoscience and nanotechnology, 2014-12, Vol.5 (4), p.45016-4 [Peer Reviewed Journal]

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Title:
Detecting the golgi protein 73 of liver cancer with micro cantilever
Author: Le, Thi Thanh Tuyen ; Pham, Van Tho ; Phan, Thanh Nhat Khoa ; Pham, Van Binh ; Le, Van Thao ; Tong, Duy Hien
Subjects: AFP ; Antibodies ; biomarker ; Biomarkers ; GP73 ; Human ; microcantilever ; Nanostructure ; Nanotechnology ; Proteins ; Serums ; Silicon nitride
Is Part Of: Advances in natural sciences. Nanoscience and nanotechnology, 2014-12, Vol.5 (4), p.45016-4
Description: Golgi protein 73 (GP73) is a potential serum biomarker used in diagnosing human hepatocellular carcinoma (HCC). Compared to alpha-fetoprotein, detection of GP73 is expected to give better sensitivity and specificity and thus offers a better method for diagnosis of HCC at an early stage. In this paper, silicon nitride microcantilever was used to detect GP73. The cantilever was modified through many steps to contain antibody of GP73. The result shows that the cantilever can be used as a label-free sensor to detect this kind of biomarker.
Publisher: IOP Publishing
Language: English
Identifier: ISSN: 2043-6262
ISSN: 2043-6254
EISSN: 2043-6262
DOI: 10.1088/2043-6262/5/4/045016
CODEN: ANSNCK
Source: IOP Publishing Free Content
IOPscience (Open Access)
GFMER Free Medical Journals

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