Language:

Inflammatory effects of acute and chronic capsaicin treatment on rat paw

Phytotherapy research, 1988-12, Vol.2 (4), p.175-179 [Peer Reviewed Journal]

Full text available

Citations Cited by

Title:
Inflammatory effects of acute and chronic capsaicin treatment on rat paw
Author: De, A.K ; Ghosh, J.J
Subjects: anti-inflammatory agents ; anti-inflammatory effects ; capsaicin ; Capsicum frutescens ; Capsicum frutescens: capsaicin ; hooves and claws ; inflammatory ; rats
Is Part Of: Phytotherapy research, 1988-12, Vol.2 (4), p.175-179
Description: Capsaicin extracted from natural sources (Capsicum frutescens) and standard capsaicin (Sigma Chemicals) were used in this study. On acute treatment capsaicin produced a dose‐related inflammatory response in rat paw as measured by the volume displacement method. This response was found to be synergestic when injected with carrageenan. Preliminary experiments showed that pretreatment with diphenhydramine‐HCl produced a significant inhibition of this acute capsaicin induced paw oedema, whereas indomethacin and methysergide were ineffective in blocking paw oedema. On the other hand, chronically capsaicin treated rats (for 10 days) showed a significant inhibition of paw oedema when treated with either carregeenan or a single high dose of capsaicin. Both the extracted and the standard capsaicin showed a similar type of response in all experiments.
Publisher: Chichester, UK: John Wiley & Sons, Ltd
Language: English
Identifier: ISSN: 0951-418X
EISSN: 1099-1573
DOI: 10.1002/ptr.2650020405
Source: Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Searching Remote Databases, Please Wait