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Endometrial cytokines in patients with and without endometriosis evaluated for infertility

Fertility and sterility, 2022-03, Vol.117 (3), p.629-640 [Peer Reviewed Journal]

2021 ;Copyright © 2021. Published by Elsevier Inc. ;info:eu-repo/semantics/openAccess ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2021.11.024 ;PMID: 35125185

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  • Title:
    Endometrial cytokines in patients with and without endometriosis evaluated for infertility
  • Author: Jørgensen, Hilde ; Fedorcsak, Peter ; Isaacson, Keith ; Tevonian, Erin ; Xiao, Amy ; Beste, Michael ; Qvigstad, Erik ; Lauffenburger, Douglas ; Griffith, Linda
  • Subjects: Adult ; Biopsy - methods ; Cohort Studies ; Cytokine ; Cytokines - metabolism ; endometrial biopsy ; endometriosis ; Endometriosis - diagnosis ; Endometriosis - metabolism ; Endometrium - metabolism ; Endometrium - pathology ; Female ; Follow-Up Studies ; Humans ; infertility ; Infertility, Female - diagnosis ; Infertility, Female - metabolism ; Laparoscopy - methods ; Prospective Studies ; Young Adult
  • Is Part Of: Fertility and sterility, 2022-03, Vol.117 (3), p.629-640
  • Description: To evaluate whether endometrial molecular profiles distinguish subsets of patients according to clinical characteristics, and to infer dysregulated immune networks, by measuring cytokines, chemokines, and growth factors in endometrial biopsy specimens from a cohort of infertile women with a high incidence of endometriosis. Prospective cohort study. Department of Gynecology at a university hospital. Patients undergoing laparoscopy for infertility assessment (n = 103). Endometrial biopsies were performed during surgery. Fertility outcome and clinical parameters were registered preoperatively and after 6 months. The concentrations of 48 factors in endometrial biopsy specimens were analyzed with respect to clinical status in univariate and multivariate frameworks. The concentrations of 44 factors from endometrial tissues of 74 patients were suitable for analysis. Although the tissue concentrations of interleukin (IL)15, IL-7, and interferon γ-induced protein (IP)-10 were individually lower in patients with endometriosis than in those without endometriosis, the differences were not significant after multiple comparison. However, multivariate modeling incorporating covariation showed separation between subsets of endometriotic and nonendometriotic patients, based predominantly on IP-10, monocyte chemoattractant protein-1, IL-16, and IL-18; this result was independent of cycle and fertility status. Analysis restricted to endometrial tissues from the secretory phase separated endometriotic and nonendometriotic patients by a combination of IL-15, IP-10, monocyte chemoattractant protein-1, IL-16, and IL-18. This combination suggests a uterine natural killer cell defect. We found no significant correlations between endometrial cytokines and fertility outcome. A molecular signature in endometrial tissue was able to distinguish endometriotic from nonendometriotic patients, implicating uterine natural killer cells in endometriosis. Citoquinas endometriales en pacientes con y sin endometriosis evaluadas por infertilidad. Evaluar si los perfiles moleculares del endometrio distinguen subconjuntos de pacientes según características clínicas, e inferir redes inmunológicas desreguladas, midiendo citoquinas, quimiocinas y factores de crecimiento en especímenes de biopsias endometriales de una cohorte de mujeres con una alta incidencia de endometriosis. Estudio prospectivo de cohorte. Departamento de ginecología de un hospital universitario. Pacientes sometidas a laparoscopia para evaluación de infertilidad. Se realizaron biopsias endometriales durante la cirugía. Se registraron los resultados de fertilidad y parámetros clínicos antes y 6 meses después de la cirugía. Las concentraciones de 48 factores en especímenes de biopsia endometrial se analizaron con respecto al estatus clínico en marcos univariable y multivariable. Las concentraciones de 44 actores de tejido endometrial de 74 pacientes fueron adecuadas para el análisis. Aunque las concentraciones de interleucina (IL) 15, IL-7 e IL-10 fueron individualmente menores en las pacientes con endometriosis que en aquellas sin endometriosis, las diferencias no fueron significativas tras la comparación múltiple. Sin embargo, un modelo multivariable incorporando covarianza mostró separación entre subgrupos de pacientes con y sin endometriosis, basados principalmente en IP-10, MCP-1, IL-16 e IL-18. Este resultado fue independiente del ciclo y el estado de fertilidad. Un análisis restringido a tejidos endometriales de fase secretoria separó a pacientes con y sin endometriosis mediante una combinación de IL-15, IP-10, MCP-1, IL-16 e IL-18. Esta combinación sugiere un defecto de células NK. No hallamos correlaciones significativas entre citoquinas endometriales y resultados de fertilidad. Una firma molecular en tejido endometrial fue capaz de distinguir pacientes con y sin endometriosis, implicando a las células NK en la endometriosis.
  • Publisher: United States: Elsevier Inc
  • Language: English;Norwegian
  • Identifier: ISSN: 0015-0282
    EISSN: 1556-5653
    DOI: 10.1016/j.fertnstert.2021.11.024
    PMID: 35125185
  • Source: MEDLINE
    NORA Norwegian Open Research Archives
    Alma/SFX Local Collection
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