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Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population-based study of 52,856 individuals. The HUNT Study, Norway

Diabetic medicine, 2022-06, Vol.39 (6), p.e14829 [Peer Reviewed Journal]

2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. ;info:eu-repo/semantics/openAccess ;ISSN: 0742-3071 ;EISSN: 1464-5491 ;DOI: 10.1111/dme.14829 ;PMID: 35288977

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  • Title:
    Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population-based study of 52,856 individuals. The HUNT Study, Norway
  • Author: Bjarkø, Vera Vik ; Haug, Eirin B ; Sørgjerd, Elin P ; Stene, Lars C ; Ruiz, Paz Lopez-Doriga ; Birkeland, Kåre I ; Berg, Tore Julsrud ; Gulseth, Hanne Løvdal ; Iversen, Marjolein M ; Langhammer, Arnulf ; Åsvold, Bjørn Olav
  • Subjects: Blood Glucose ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Glycated Hemoglobin A - metabolism ; Heart Disease Risk Factors ; Humans ; Prediabetic State - diagnosis ; Prediabetic State - epidemiology ; Prevalence ; Risk Factors
  • Is Part Of: Diabetic medicine, 2022-06, Vol.39 (6), p.e14829
  • Description: We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population-based study. All residents aged ≥20 years in the Nord-Trøndelag region, Norway, were invited to the HUNT4 Survey in 2017-2019, and 54% attended. Diagnosed diabetes was self-reported, and in those reporting no diabetes HbA1c was used to classify undiagnosed diabetes (≥48 mmol/mol [6.5%]) and prediabetes (39-47 mmol/mol [5.7%-6.4%]). We estimated the age- and sex-standardized prevalence of these conditions and their age- and sex-adjusted associations with other cardiovascular risk factors. Among 52,856 participants, the prevalence of diabetes was 6.0% (95% CI 5.8, 6.2), of which 11.1% were previously undiagnosed (95% CI 10.1, 12.2). The prevalence of prediabetes was 6.4% (95% CI 6.2, 6.6). Among participants with undiagnosed diabetes, 58% had HbA1c of 48-53 mmol/mol (6.5%-7.0%), and only 14% (i.e., 0.1% of the total study population) had HbA1c >64 mmol/mol (8.0%). Compared with normoglycaemic participants, those with undiagnosed diabetes or prediabetes had higher body mass index, waist circumference, systolic blood pressure, triglycerides and C-reactive protein but lower low-density lipoprotein cholesterol (all p < 0.001). Participants with undiagnosed diabetes had less favourable values for every measured risk factor compared with those with diagnosed diabetes. The low prevalence of undiagnosed diabetes suggests that the current case-finding-based diagnostic practice is well-functioning. Few participants with undiagnosed diabetes had very high HbA1c levels indicating severe hyperglycaemia. Nonetheless, participants with undiagnosed diabetes had a poorer cardiovascular risk profile compared with participants with known or no diabetes.
  • Publisher: England
  • Language: English;Norwegian
  • Identifier: ISSN: 0742-3071
    EISSN: 1464-5491
    DOI: 10.1111/dme.14829
    PMID: 35288977
  • Source: NORA Norwegian Open Research Archives
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