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Exosomes and cardiac repair after myocardial infarction

Circulation research, 2014-01, Vol.114 (2), p.333-344 [Peer Reviewed Journal]

ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/circresaha.114.300639 ;PMID: 24436429

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Title:
Exosomes and cardiac repair after myocardial infarction
Author: Sahoo, Susmita ; Losordo, Douglas W
Subjects: Animals ; Cell Communication ; Exosomes - metabolism ; Gene Expression Regulation ; Humans ; Myocardial Infarction - genetics ; Myocardial Infarction - metabolism ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardial Infarction - surgery ; Myocardium - metabolism ; Myocardium - pathology ; Regeneration ; RNA, Messenger - metabolism ; Signal Transduction ; Stem Cell Transplantation
Is Part Of: Circulation research, 2014-01, Vol.114 (2), p.333-344
Description: Myocardial infarction is a leading cause of death among all cardiovascular diseases. The analysis of molecular mechanisms by which the ischemic myocardium initiates repair and remodeling indicates that secreted soluble factors are key players in communication to local and distant tissues, such as bone marrow. Recently, actively secreted membrane vesicles, including exosomes, are being recognized as new candidates with important roles in intercellular and tissue-level communication. In this review, we critically examine the emerging role of exosomes in local and distant microcommunication mechanisms after myocardial infarction. A comprehensive understanding of the role of exosomes in cardiac repair after myocardial infarction could bridge a major gap in knowledge of the repair mechanism after myocardial injury.
Publisher: United States
Language: English
Identifier: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/circresaha.114.300639
PMID: 24436429
Source: GFMER Free Medical Journals
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Exosomes and cardiac repair after myocardial infarction

ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/circresaha.114.300639 ;PMID: 24436429

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