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First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera)

BMC genomics, 2021-04, Vol.22 (1), p.255-255, Article 255 [Peer Reviewed Journal]

COPYRIGHT 2021 BioMed Central Ltd. ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1471-2164 ;EISSN: 1471-2164 ;DOI: 10.1186/s12864-021-07567-5 ;PMID: 33838656

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Title:
First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera)
Author: Dong, Yibo ; Li, Ping ; Li, Ping ; Chen, Chao
Subjects: Biological activity ; Biosynthesis ; Botanical research ; Broussonetia ; Broussonetia - metabolism ; Carbon fixation ; Cell cycle ; Cellular structure ; China ; Citric acid ; Dicarboxylic acids ; Gene expression ; Genetic aspects ; Genomics ; Glyoxylic acid ; Herbal medicine ; Lysine ; Lysine - metabolism ; Lysine succinylation ; Mass spectrometry ; Medicinal plants ; Metabolism ; Microorganisms ; Morus ; Mulberry ; Oxidative metabolism ; Oxidative phosphorylation ; Paper mulberry ; Peptides ; Phenols ; Phosphorylation ; Photosynthesis ; Physiological aspects ; Physiology ; Plant species ; Post-translation ; Post-translational modification ; Posttranslational modification ; Protein Processing, Post-Translational ; Protein structure ; Proteins ; Proteomics ; Ribosomes ; Scientific imaging ; Signal transduction ; Species ; Structure-function relationships ; Succinic Acid ; Traditional Chinese medicine ; Tricarboxylic acid cycle
Is Part Of: BMC genomics, 2021-04, Vol.22 (1), p.255-255, Article 255
Description: Lysine succinylation is a naturally occurring post-translational modification (PTM) that is ubiquitous in organisms. Lysine succinylation plays important roles in regulating protein structure and function as well as cellular metabolism. Global lysine succinylation at the proteomic level has been identified in a variety of species; however, limited information on lysine succinylation in plant species, especially paper mulberry, is available. Paper mulberry is not only an important plant in traditional Chinese medicine, but it is also a tree species with significant economic value. Paper mulberry is found in the temperate and tropical zones of China. The present study analyzed the effects of lysine succinylation on the growth, development, and physiology of paper mulberry. A total of 2097 lysine succinylation sites were identified in 935 proteins associated with the citric acid cycle (TCA cycle), glyoxylic acid and dicarboxylic acid metabolism, ribosomes and oxidative phosphorylation; these pathways play a role in carbon fixation in photosynthetic organisms and may be regulated by lysine succinylation. The modified proteins were distributed in multiple subcellular compartments and were involved in a wide variety of biological processes, such as photosynthesis and the Calvin-Benson cycle. Lysine-succinylated proteins may play key regulatory roles in metabolism, primarily in photosynthesis and oxidative phosphorylation, as well as in many other cellular processes. In addition to the large number of succinylated proteins associated with photosynthesis and oxidative phosphorylation, some proteins associated with the TCA cycle are succinylated. Our study can serve as a reference for further proteomics studies of the downstream effects of succinylation on the physiology and biochemistry of paper mulberry.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2164
EISSN: 1471-2164
DOI: 10.1186/s12864-021-07567-5
PMID: 33838656
Source: SpringerOpen
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
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First comprehensive analysis of lysine succinylation in paper mulberry (Broussonetia papyrifera)

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