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Comprehensive Profiling of Paper Mulberry ( Broussonetia papyrifera ) Crotonylome Reveals the Significance of Lysine Crotonylation in Young Leaves

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1173 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms23031173 ;PMID: 35163093

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Title:
Comprehensive Profiling of Paper Mulberry ( Broussonetia papyrifera ) Crotonylome Reveals the Significance of Lysine Crotonylation in Young Leaves
Author: Dong, Yibo ; Chen, Chao
Subjects: Amino acids ; Annotations ; Bioinformatics ; Biological activity ; Biosynthesis ; Broussonetia ; Broussonetia - genetics ; Broussonetia - growth & development ; Broussonetia - metabolism ; Carbon ; Carbon fixation ; Cellular stress response ; Chromatography ; Crotonates - chemistry ; Flavonoids ; Gene expression ; Gene Expression Regulation, Plant ; Hsp70 protein ; Lignin ; Lysine ; Lysine - chemistry ; Lysine - metabolism ; lysine crotonylation ; Mass spectrometry ; Metabolism ; Network analysis ; paper mulberry ; Peptides ; Photosynthesis ; Physiology ; Plant cells ; Plant Leaves - genetics ; Plant Leaves - growth & development ; Plant Leaves - metabolism ; plant metabolism ; Plant Proteins - chemistry ; Plant Proteins - genetics ; Plant Proteins - metabolism ; posttranslational modification ; PPI ; Proteasomes ; Protein Processing, Post-Translational ; Proteins ; Proteome - metabolism ; Proteomes ; Proteomics ; Scientific imaging ; Tricarboxylic acid cycle
Is Part Of: International journal of molecular sciences, 2022-01, Vol.23 (3), p.1173
Description: Lysine crotonylation is a newly discovered and reversible posttranslational modification involved in various biological processes, especially metabolism regulation. A total of 5159 lysine crotonylation sites in 2272 protein groups were identified. Twenty-seven motifs were found to be the preferred amino acid sequences for crotonylation sites. Functional annotation analyses revealed that most crotonylated proteins play important roles in metabolic processes and photosynthesis. Bioinformatics analysis suggested that lysine crotonylation preferentially targets a variety of important biological processes, including ribosome, glyoxylate and dicarboxylate metabolism, carbon fixation in photosynthetic organisms, proteasome and the TCA cycle, indicating lysine crotonylation is involved in the common mechanism of metabolic regulation. A protein interaction network analysis revealed that diverse interactions are modulated by protein crotonylation. These results suggest that lysine crotonylation is involved in a variety of biological processes. HSP70 is a crucial protein involved in protecting plant cells and tissues from thermal or abiotic stress responses, and HSP70 protein was found to be crotonylated in paper mulberry. This systematic analysis provides the first comprehensive analysis of lysine crotonylation in paper mulberry and provides important resources for further study on the regulatory mechanism and function of the lysine crotonylated proteome.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms23031173
PMID: 35163093
Source: DOAJ Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central

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Comprehensive Profiling of Paper Mulberry ( Broussonetia papyrifera ) Crotonylome Reveals the Significance of Lysine Crotonylation in Young Leaves

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