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Mechanisms linking obesity with cardiovascular disease

Nature, 2006-12, Vol.444 (7121), p.875-880 [Peer Reviewed Journal]

COPYRIGHT 2006 Nature Publishing Group ;COPYRIGHT 2006 Nature Publishing Group ;Copyright Nature Publishing Group Dec 14, 2006 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;EISSN: 1476-4679 ;DOI: 10.1038/nature05487 ;PMID: 17167476 ;CODEN: NATUAS

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Title:
Mechanisms linking obesity with cardiovascular disease
Author: Gaal, L.F. van ; Mertens, I.L ; Block, C.E. de
Subjects: Adiposity ; Cardiovascular disease ; cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - pathology ; Cardiovascular Diseases - physiopathology ; Diabetes ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Exercise ; human diseases ; Humans ; Insulin ; Insulin Resistance ; literature reviews ; Obesity ; Obesity - complications ; Obesity - pathology ; Obesity - physiopathology ; Oxidative Stress ; pathophysiology ; Risk factors ; Smoking
Is Part Of: Nature, 2006-12, Vol.444 (7121), p.875-880
Description: Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0028-0836
EISSN: 1476-4687
EISSN: 1476-4679
DOI: 10.1038/nature05487
PMID: 17167476
CODEN: NATUAS
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

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Mechanisms linking obesity with cardiovascular disease

COPYRIGHT 2006 Nature Publishing Group ;COPYRIGHT 2006 Nature Publishing Group ;Copyright Nature Publishing Group Dec 14, 2006 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;EISSN: 1476-4679 ;DOI: 10.1038/nature05487 ;PMID: 17167476 ;CODEN: NATUAS

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