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1,25-Dihydroxyvitamin D3 Provides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function

Nutrients, 2023-11, Vol.15 (21), p.4697 [Peer Reviewed Journal]

2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2072-6643 ;EISSN: 2072-6643 ;DOI: 10.3390/nu15214697

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  • Title:
    1,25-Dihydroxyvitamin D3 Provides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function
  • Author: Wei, Yujia ; Wang, Tingmei ; Nie, Xiaoqi ; Shi, Zeqi ; Liu, Zhong ; Zeng, Ying ; Pan, Ronghua ; Zhang, Ri ; Deng, Yunhua ; Li, Dong
  • Subjects: Autoimmune diseases ; CD8+ T cells ; Cross-sectional studies ; Cytotoxicity ; Disease ; Glucose ; glycolysis ; Kinases ; Laboratory animals ; Light therapy ; Lymphocytes ; Metabolism ; Metabolites ; Patients ; Penicillin ; Skin ; Vitamin D ; Vitamin deficiency ; Vitiligo
  • Is Part Of: Nutrients, 2023-11, Vol.15 (21), p.4697
  • Description: Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study aimed to elucidate the immunomodulatory effects of 1,25(OH)₂D₃ in vitiligo. Cross-sectional relationships between serum 1,25(OH)₂D₃ levels and disease characteristics were investigated in 327 patients with vitiligo. The immunomodulatory and therapeutic effects of 1,25(OH)₂D₃ were then investigated in vivo and in vitro, respectively. We found that 1,25(OH)₂D₃ deficiency was associated with hyperactivity of CD8+ T cells in the vitiligo cohort. In addition, 1,25(OH)₂D₃ suppressed glycolysis by activating the AMP-activated protein kinase (AMPK) signaling pathway, thereby inhibiting the proliferation, cytotoxicity and aberrant activation of CD8+ T cells. Finally, the in vivo administration of 1,25(OH)₂D₃ to melanocyte-associated vitiligo (MAV) mice reduced the infiltration and function of CD8+ T cells and promoted repigmentation. In conclusion, 1,25(OH)₂D₃ may serve as an essential biomarker of the progression and severity of vitiligo. The modulation of autoreactive CD8+ T cell function and glycolysis by 1,25(OH)₂D₃ may be a novel approach for treating vitiligo.
  • Publisher: Basel: MDPI AG
  • Language: English
  • Identifier: ISSN: 2072-6643
    EISSN: 2072-6643
    DOI: 10.3390/nu15214697
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    Directory of Open Access Journals
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
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